8JPX

Cryo-EM structure of PfAgo-guide DNA-target DNA complex

Summary for 8JPX

• Entry DOI: 10.2210/pdb8jpx/pdb
• EMDB information: 36489
• Descriptor: Protein argonaute, Guide DNA, Target DNA, ... (5 entities in total)
• Functional Keywords: nuclease, gene regulation
• Biological source: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1); More
• Total number of polymer chains: 8
• Total formula weight: 205552.00

Authors

Zhuang, L. (deposition date: 2023-06-13, release date: 2024-01-31, Last modification date: 2024-05-01)

• Primary citation: Wang, L.,Chen, W.,Zhang, C.,Xie, X.,Huang, F.,Chen, M.,Mao, W.,Yu, N.,Wei, Q.,Ma, L.,Li, Z.; Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute.; Mol.Cell, 84:675-686.e4, 2024; PubMed: 38295801; DOI: 10.1016/j.molcel.2024.01.004

Experimental method

ELECTRON MICROSCOPY (2.9 Å)