8JPX
Cryo-EM structure of PfAgo-guide DNA-target DNA complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0044355 | biological_process | clearance of foreign intracellular DNA |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0044355 | biological_process | clearance of foreign intracellular DNA |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:15284453, ECO:0000305|PubMed:15800637 |
| Chain | Residue | Details |
| B | ASP558 | |
| B | ASP628 | |
| A | ASP558 | |
| A | ASP628 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q746M7 |
| Chain | Residue | Details |
| B | GLU596 | |
| A | GLU596 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:15800637 |
| Chain | Residue | Details |
| B | HIS745 | |
| A | HIS745 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q746M7 |
| Chain | Residue | Details |
| B | ASP558 | |
| B | VAL770 | |
| A | ASP558 | |
| A | VAL770 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q746M7, ECO:0000269|PubMed:15800637, ECO:0007744|PDB:1Z25 |
| Chain | Residue | Details |
| B | ASP628 | |
| A | ASP628 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15800637, ECO:0007744|PDB:1Z25 |
| Chain | Residue | Details |
| B | HIS745 | |
| A | HIS745 |
