4OLA

Crystal Structure of Human Argonaute2

Replaces:  4EI1

Summary for 4OLA

Related4OLB
DescriptorProtein argonaute-2, 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', PHENOL, ... (5 entities in total)
Functional Keywordsrna-binding protein, rna interference, protein-rna complex, ago, hydrolase-rna complex, hydrolase/rna
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, P-body Q9UKV8
Total number of polymer chains2
Total molecular weight100756.45
Authors
Schirle, N.T.,MacRae, I.J. (deposition date: 2014-01-23, release date: 2014-02-05)
Primary citation
Schirle, N.T.,MacRae, I.J.
The crystal structure of human Argonaute2.
Science, 336:1037-1040, 2012
PubMed: 22539551 (PDB entries with the same primary citation)
DOI: 10.1126/science.1221551
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.25370.1%4.7%8.4%0.46MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution