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7NHU
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BU of 7nhu by Molmil
Crystal structure of desB30 insulin produced by cell free protein synthesis
Descriptor: Insulin
Authors:Johansson, E.
Deposit date:2021-02-11
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein.
Protein Expr.Purif., 186, 2021
6OR0
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BU of 6or0 by Molmil
Crystal structure of Insulin from Non-merohedrally twinned crystals
Descriptor: Insulin chain A, Insulin chain B
Authors:Sevvana, M, Ruf, M, Uson, I, Sheldrick, G.M, Herbst-Irmer, R.
Deposit date:2019-04-29
Release date:2019-12-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Non-merohedral twinning: from minerals to proteins.
Acta Crystallogr D Struct Biol, 75, 2019
7JP3
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BU of 7jp3 by Molmil
Des-B29,B30-insulin
Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ...
Authors:Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A.
Deposit date:2020-08-07
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Des-B29,B30-insulin
To Be Published
6CK2
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BU of 6ck2 by Molmil
Insulin analog containing a YB26W mutation
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Rege, N.K, Yee, V.C, Weiss, M.A.
Deposit date:2018-02-27
Release date:2018-06-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.
J. Biol. Chem., 293, 2018
2ZP6
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BU of 2zp6 by Molmil
Crystal structure of Bovine Insulin (Hexameric form)
Descriptor: Insulin A chain, Insulin B chain, ZINC ION
Authors:Jaimohan, S.M, Naresh, M.D, Mandal, A.B.
Deposit date:2008-06-27
Release date:2008-07-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Crystal structure of Bovine Insulin (Hexameric form)
To be Published
8HGZ
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BU of 8hgz by Molmil
Crystal structure of insulin
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:DeMirci, H, Ayan, E.
Deposit date:2022-11-16
Release date:2024-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative Study of High-Resolution LysB29(N epsilon-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions
Crystals, 13, 2023
5HQI
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BU of 5hqi by Molmil
Insulin with proline analog HzP at position B28 in the T2 state
Descriptor: Insulin A-Chain, Insulin B-Chain
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-21
Release date:2017-01-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
5HPR
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BU of 5hpr by Molmil
Insulin with proline analog HyP at position B28 in the T2 state
Descriptor: GLYCEROL, Insulin A-Chain, Insulin B-Chain, ...
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-21
Release date:2017-01-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
3AIY
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BU of 3aiy by Molmil
R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, REFINED AVERAGE STRUCTURE
Descriptor: PHENOL, PROTEIN (INSULIN)
Authors:O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J.
Deposit date:1998-12-29
Release date:2000-02-28
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure.
J.Biomol.NMR, 16, 2000
8HSF
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BU of 8hsf by Molmil
Insulin triple mutant INS-RQD
Descriptor: Insulin A chain, Insulin B chain
Authors:Kundapura, S.V, Rao, S.S, Kulal, A, Ramagopal, U.A.
Deposit date:2022-12-19
Release date:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Insulin triple mutant INS-RQD
To Be Published
8HSK
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BU of 8hsk by Molmil
Insulin single mutant INS-Q
Descriptor: Insulin A chain, Insulin B chain, SULFATE ION
Authors:Rao, S.S, Kundapura, S.V, Kulal, A, Ramagopal, U.A.
Deposit date:2022-12-19
Release date:2023-12-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Insulin single mutant INS-Q
To Be Published
2ZPP
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BU of 2zpp by Molmil
Neutron crystal structure of cubic insulin at pD9
Descriptor: Insulin A chain, Insulin B chain
Authors:Ishikawa, T, Tanaka, I, Niimura, N.
Deposit date:2008-07-26
Release date:2008-10-28
Last modified:2023-11-01
Method:NEUTRON DIFFRACTION (2.5 Å)
Cite:An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis
Biochem.Biophys.Res.Commun., 376, 2008
5HRQ
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BU of 5hrq by Molmil
Insulin with proline analog HzP at position B28 in the R6 state
Descriptor: CHLORIDE ION, Insulin A-Chain, Insulin B-Chain, ...
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-24
Release date:2017-01-25
Last modified:2020-01-15
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
5HPU
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BU of 5hpu by Molmil
Insulin with proline analog HyP at position B28 in the R6 state
Descriptor: CHLORIDE ION, Insulin, chain A, ...
Authors:Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A.
Deposit date:2016-01-21
Release date:2017-01-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation.
J. Am. Chem. Soc., 139, 2017
8IPZ
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BU of 8ipz by Molmil
Crystal structure of insulin detemir
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:DeMirci, H, Ayan, E.
Deposit date:2023-03-15
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of insulin detemir
To Be Published
4RXW
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BU of 4rxw by Molmil
Crystal Structure of the cobalt human insulin derivative
Descriptor: COBALT (II) ION, Insulin A chain, Insulin B chain
Authors:Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D.
Deposit date:2014-12-12
Release date:2015-01-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal Structure of the cobalt human insulin derivative
TO BE PUBLISHED
7ELJ
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BU of 7elj by Molmil
Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping
Descriptor: IS1, Insulin A Chain, Insulin B chain
Authors:Banerjee, N.
Deposit date:2021-04-11
Release date:2021-04-28
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping.
Iscience, 24, 2021
4UNE
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BU of 4une by Molmil
Human insulin B26Phe mutant crystal structure
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
Authors:Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
Deposit date:2014-05-28
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
4UNG
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BU of 4ung by Molmil
Human insulin B26Asn mutant crystal structure
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
Authors:Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
Deposit date:2014-05-28
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
4UNH
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BU of 4unh by Molmil
Human insulin B26Gly mutant crystal structure
Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION
Authors:Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M.
Deposit date:2014-05-28
Release date:2014-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70, 2014
3BXQ
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BU of 3bxq by Molmil
The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition
Descriptor: ZINC ION, insulin A chain, insulin B chain
Authors:Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition.
J.Biol.Chem., 283, 2008
2KQQ
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BU of 2kqq by Molmil
NMR structure of human insulin mutant gly-b8-d-ala, his-b10-asp, pro-b28-lys, lys-b29-pro, 20 structures
Descriptor: Insulin A chain, Insulin B chain
Authors:Hua, Q.X, Wan, Z.L, Zhao, M, Jia, W, Huang, K, Weiss, M.A.
Deposit date:2009-11-13
Release date:2010-11-24
Last modified:2021-10-13
Method:SOLUTION NMR
Cite:Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog.
To be Published
2KJU
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BU of 2kju by Molmil
NMR structure of human insulin mutant glu-b21-d-glu, his-b10 asp pro-b28-lys, lys-b29-pro, 20 structures
Descriptor: Insulin
Authors:Hua, Q.X, Huang, K, Hu, S.Q, Katsoyanni, P, Weiss, M.A.
Deposit date:2009-06-10
Release date:2010-06-16
Last modified:2021-10-13
Method:SOLUTION NMR
Cite:Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn
To be Published
2KQP
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BU of 2kqp by Molmil
NMR Structure of Proinsulin
Descriptor: Insulin
Authors:Yang, Y, Hua, Q.X, Mackin, R.B, Weiss, M.A.
Deposit date:2009-11-12
Release date:2010-01-26
Last modified:2021-10-13
Method:SOLUTION NMR
Cite:Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
J.Biol.Chem., 285, 2010
2KXK
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BU of 2kxk by Molmil
Human Insulin Mutant A22Gly-B31Lys-B32Arg
Descriptor: Insulin A chain, Insulin B chain
Authors:Bocian, W, Kozerski, L.
Deposit date:2010-05-07
Release date:2011-06-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Novel recombinant insulin analogue with flexible C - terminus in B chain. NMR structure of biosynthetic engineered A22G-B31K-B32R human insulin monomer in water /acetonitrile solution.
To be Published

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