PDB: 438 resultsInfo pagesStatus searchChemie searchBIRD

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7NHU	Crystal structure of desB30 insulin produced by cell free protein synthesis Descriptor: Insulin Authors: Johansson, E. Deposit date: 2021-02-11 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein. Protein Expr.Purif., 186, 2021
6OR0	Crystal structure of Insulin from Non-merohedrally twinned crystals Descriptor: Insulin chain A, Insulin chain B Authors: Sevvana, M, Ruf, M, Uson, I, Sheldrick, G.M, Herbst-Irmer, R. Deposit date: 2019-04-29 Release date: 2019-12-11 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Non-merohedral twinning: from minerals to proteins. Acta Crystallogr D Struct Biol, 75, 2019
7JP3	Des-B29,B30-insulin Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ... Authors: Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A. Deposit date: 2020-08-07 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Des-B29,B30-insulin To Be Published
6CK2	Insulin analog containing a YB26W mutation Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Rege, N.K, Yee, V.C, Weiss, M.A. Deposit date: 2018-02-27 Release date: 2018-06-13 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions. J. Biol. Chem., 293, 2018
2ZP6	Crystal structure of Bovine Insulin (Hexameric form) Descriptor: Insulin A chain, Insulin B chain, ZINC ION Authors: Jaimohan, S.M, Naresh, M.D, Mandal, A.B. Deposit date: 2008-06-27 Release date: 2008-07-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Crystal structure of Bovine Insulin (Hexameric form) To be Published
8HGZ	Crystal structure of insulin Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: DeMirci, H, Ayan, E. Deposit date: 2022-11-16 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Comparative Study of High-Resolution LysB29(N epsilon-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions Crystals, 13, 2023
5HQI	Insulin with proline analog HzP at position B28 in the T2 state Descriptor: Insulin A-Chain, Insulin B-Chain Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-21 Release date: 2017-01-25 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (0.97 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
5HPR	Insulin with proline analog HyP at position B28 in the T2 state Descriptor: GLYCEROL, Insulin A-Chain, Insulin B-Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-21 Release date: 2017-01-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.33 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
3AIY	R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, REFINED AVERAGE STRUCTURE Descriptor: PHENOL, PROTEIN (INSULIN) Authors: O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. Deposit date: 1998-12-29 Release date: 2000-02-28 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
8HSF	Insulin triple mutant INS-RQD Descriptor: Insulin A chain, Insulin B chain Authors: Kundapura, S.V, Rao, S.S, Kulal, A, Ramagopal, U.A. Deposit date: 2022-12-19 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Insulin triple mutant INS-RQD To Be Published
8HSK	Insulin single mutant INS-Q Descriptor: Insulin A chain, Insulin B chain, SULFATE ION Authors: Rao, S.S, Kundapura, S.V, Kulal, A, Ramagopal, U.A. Deposit date: 2022-12-19 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Insulin single mutant INS-Q To Be Published
2ZPP	Neutron crystal structure of cubic insulin at pD9 Descriptor: Insulin A chain, Insulin B chain Authors: Ishikawa, T, Tanaka, I, Niimura, N. Deposit date: 2008-07-26 Release date: 2008-10-28 Last modified: 2023-11-01 Method: NEUTRON DIFFRACTION (2.5 Å) Cite: An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis Biochem.Biophys.Res.Commun., 376, 2008
5HRQ	Insulin with proline analog HzP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A-Chain, Insulin B-Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-24 Release date: 2017-01-25 Last modified: 2020-01-15 Method: X-RAY DIFFRACTION (1.28 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
5HPU	Insulin with proline analog HyP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin, chain A, ... Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-21 Release date: 2017-01-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
8IPZ	Crystal structure of insulin detemir Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: DeMirci, H, Ayan, E. Deposit date: 2023-03-15 Release date: 2023-12-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of insulin detemir To Be Published
4RXW	Crystal Structure of the cobalt human insulin derivative Descriptor: COBALT (II) ION, Insulin A chain, Insulin B chain Authors: Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D. Deposit date: 2014-12-12 Release date: 2015-01-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Crystal Structure of the cobalt human insulin derivative TO BE PUBLISHED
7ELJ	Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping Descriptor: IS1, Insulin A Chain, Insulin B chain Authors: Banerjee, N. Deposit date: 2021-04-11 Release date: 2021-04-28 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping. Iscience, 24, 2021
4UNE	Human insulin B26Phe mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNG	Human insulin B26Asn mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNH	Human insulin B26Gly mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
3BXQ	The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition Descriptor: ZINC ION, insulin A chain, insulin B chain Authors: Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A. Deposit date: 2008-01-14 Release date: 2008-05-20 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283, 2008
2KQQ	NMR structure of human insulin mutant gly-b8-d-ala, his-b10-asp, pro-b28-lys, lys-b29-pro, 20 structures Descriptor: Insulin A chain, Insulin B chain Authors: Hua, Q.X, Wan, Z.L, Zhao, M, Jia, W, Huang, K, Weiss, M.A. Deposit date: 2009-11-13 Release date: 2010-11-24 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog. To be Published
2KJU	NMR structure of human insulin mutant glu-b21-d-glu, his-b10 asp pro-b28-lys, lys-b29-pro, 20 structures Descriptor: Insulin Authors: Hua, Q.X, Huang, K, Hu, S.Q, Katsoyanni, P, Weiss, M.A. Deposit date: 2009-06-10 Release date: 2010-06-16 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn To be Published
2KQP	NMR Structure of Proinsulin Descriptor: Insulin Authors: Yang, Y, Hua, Q.X, Mackin, R.B, Weiss, M.A. Deposit date: 2009-11-12 Release date: 2010-01-26 Last modified: 2021-10-13 Method: SOLUTION NMR Cite: Solution structure of proinsulin: connecting domain flexibility and prohormone processing. J.Biol.Chem., 285, 2010
2KXK	Human Insulin Mutant A22Gly-B31Lys-B32Arg Descriptor: Insulin A chain, Insulin B chain Authors: Bocian, W, Kozerski, L. Deposit date: 2010-05-07 Release date: 2011-06-01 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Novel recombinant insulin analogue with flexible C - terminus in B chain. NMR structure of biosynthetic engineered A22G-B31K-B32R human insulin monomer in water /acetonitrile solution. To be Published

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