4UNE

Human insulin B26Phe mutant crystal structure

Summary for 4UNE

Related4UNG 4UNH
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION, ... (4 entities in total)
Functional Keywordshormone, b26 site
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01308 P01308
Total number of polymer chains4
Total molecular weight11795.43
Authors
Zakova, L.,Klevtikova, E.,Lepsik, M.,Collinsova, M.,Watson, C.J.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M. (deposition date: 2014-05-28, release date: 2014-10-15, Last modification date: 2018-05-16)
Primary citation
Zakova, L.,Klevtikova, E.,Lepsik, M.,Collinsova, M.,Watson, C.J.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.
Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex
Acta Crystallogr.,Sect.D, 70:2765-, 2014
PubMed: 25286859 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004714017775
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.59 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.198103.4%1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution