4UNE

Human insulin B26Phe mutant crystal structure

Summary for 4UNE

• Entry DOI: 10.2210/pdb4une/pdb
• Related: 4UNG 4UNH
• Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION, ... (4 entities in total)
• Functional Keywords: hormone, b26 site
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 4
• Total formula weight: 11795.43

Authors

Zakova, L.,Klevtikova, E.,Lepsik, M.,Collinsova, M.,Watson, C.J.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M. (deposition date: 2014-05-28, release date: 2014-10-15, Last modification date: 2024-01-10)

• Primary citation: Zakova, L.,Klevtikova, E.,Lepsik, M.,Collinsova, M.,Watson, C.J.,Turkenburg, J.P.,Jiracek, J.,Brzozowski, A.M.; Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex; Acta Crystallogr.,Sect.D, 70:2765-, 2014; PubMed: 25286859; DOI: 10.1107/S1399004714017775

Experimental method

X-RAY DIFFRACTION (1.59 Å)