Author results

3SQD
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CRYSTAL STRUCTURE OF HUMAN PTIP BRCT5/6-GAMMA H2AX COMPLEX
Descriptor:PAX-interacting protein 1, Histone H2A.x
Authors:Yan, W., Shao, Z.H.
Deposit date:2011-07-05
Release date:2011-11-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Crystal structure of human PTIP BRCT5/6-gamma H2AX
To be Published
4Y5S
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STRUCTURE OF FTMOX1 WITH A-KETOGLUTARATE AS CO-SUBSTRATE
Descriptor:Verruculogen synthase, 2-OXOGLUTARIC ACID, FE (II) ION, ...
Authors:Yan, W., Zhang, Y.
Deposit date:2015-02-12
Release date:2015-11-04
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.543 Å)
Cite:Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme.
Nature, 527, 2015
4Y5T
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STRUCTURE OF FTMOX1 APO WITH METAL IRON
Descriptor:Verruculogen synthase, FE (II) ION, SULFATE ION, ...
Authors:Yan, W., Zhang, Y.
Deposit date:2015-02-12
Release date:2015-11-04
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme.
Nature, 527, 2015
4ZON
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STRUCTURE OF FTMOX1 WITH FUMITREMORGEN B COMPLEX
Descriptor:Verruculogen synthase, fumitremorgen B, FE (II) ION, ...
Authors:Yan, W., Zhang, Y.
Deposit date:2015-05-06
Release date:2015-11-04
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (2.112 Å)
Cite:Endoperoxide formation by an alpha-ketoglutarate-dependent mononuclear non-haem iron enzyme.
Nature, 527, 2015
5TSU
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ACTIVE CONFORMATION FOR ENGINEERED HUMAN CYSTATHIONINE GAMMA LYASE (E59N, R119L, E339V) TO DEPLETING METHIONINE
Descriptor:Cystathionine gamma-lyase, METHIONINE, SULFATE ION, ...
Authors:Yan, W., Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5TT2
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INACTIVE CONFORMATION OF ENGINEERED HUMAN CYSTATHIONINE GAMMA LYASE (E59N, R119L, E339V) TO DEPLETING METHIONINE
Descriptor:Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W., Zhang, Y.
Deposit date:2016-10-31
Release date:2017-10-11
Method:X-RAY DIFFRACTION (2.949 Å)
Cite:Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry, 56, 2017
5V43
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ENGINEERED HUMAN IGG FC DOMAIN AGLYCO801
Descriptor:Ig gamma-1 chain C region
Authors:Yan, W., Marshall, N., Zhang, Y.J.
Deposit date:2017-03-08
Release date:2017-06-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.
Nat. Immunol., 18, 2017
5V4E
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ENGINEERED HUMAN IGG FC DOMAIN GLYCO801 (FC801)
Descriptor:Ig gamma-1 chain C region, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Yan, W., Marshall, N., Zhang, Y.J.
Deposit date:2017-03-09
Release date:2017-06-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.216 Å)
Cite:IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.
Nat. Immunol., 18, 2017
4JWF
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CRYSTAL STRUCTURE OF SPTRM10(74)-SAH COMPLEX
Descriptor:tRNA (guanine(9)-N1)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ACETIC ACID
Authors:Yan, W., Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWG
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CRYSTAL STRUCTURE OF SPTRM10(74)
Descriptor:tRNA (guanine(9)-N1)-methyltransferase, ACETIC ACID
Authors:Yan, W., Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWH
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CRYSTAL STRUCTURE OF SPTRM10(FULL LENGTH)-SAH COMPLEX
Descriptor:tRNA (guanine(9)-N1)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Yan, W., Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
4JWJ
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CRYSTAL STRUCTURE OF SCTRM10(84)-SAH COMPLEX
Descriptor:tRNA (guanine(9)-N1)-methyltransferase, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Yan, W., Shao, Z.
Deposit date:2013-03-27
Release date:2013-10-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.
Nucleic Acids Res., 42, 2014
5EIG
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ENGINEERED HUMAN CYSTATHIONINE GAMMA LYASE (E59T, E339V) TO DEPLET CYSTEINE
Descriptor:Cystathionine gamma-lyase, SULFATE ION, CYSTEINE
Authors:Yan, W., Zhang, J.
Deposit date:2015-10-29
Release date:2016-11-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation
To Be Published
6NZS
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DEXTRANASE AODEX KQ11
Descriptor:Dextranase
Authors:Ren, W., Yan, W., Gu, L., Feng, Y., Dong, D., Wang, S., Wang, C., Lyu, M.
Deposit date:2019-02-14
Release date:2019-02-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus
To Be Published
3JU5
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CRYSTAL STRUCTURE OF DIMERIC ARGININE KINASE AT 1.75-A RESOLUTION
Descriptor:Arginine kinase, MAGNESIUM ION
Authors:Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z.
Deposit date:2009-09-14
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
3JU6
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CRYSTAL STRUCTURE OF DIMERIC ARGININE KINASE IN COMPLEX WITH AMPPNP AND ARGININE
Descriptor:Arginine kinase, ARGININE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wu, X., Ye, S., Guo, S., Yan, W., Bartlam, M., Rao, Z.
Deposit date:2009-09-14
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity
Faseb J., 24, 2010
3SHT
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CRYSTAL STRUCTURE OF HUMAN MCPH1 TANDEM BRCT DOMAINS
Descriptor:Microcephalin
Authors:Shao, Z.H., Li, F.D., Yan, W.
Deposit date:2011-06-17
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
J.Struct.Biol., 177, 2012
3SHV
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CRYSTAL STRUCTURE OF HUMAN MCPH1 TANDEM BRCT DOMAINS-GAMMA H2AX COMPLEX
Descriptor:Microcephalin, Histone H2A.x
Authors:Shao, Z.H., Li, F.D., Yan, W.
Deposit date:2011-06-17
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure
J.Struct.Biol., 177, 2012
6BOF
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CRYSTAL STRUCTURE OF KRAS A146T-GDP DEMONSTRATING OPEN SWITCH 1 CONFORMATION
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Bera, A.K., Yan, W., Westover, K.D.
Deposit date:2017-11-20
Release date:2019-05-22
Last modified:2019-06-19
Method:X-RAY DIFFRACTION (1.401 Å)
Cite:Tissue-Specific Oncogenic Activity of KRASA146T.
Cancer Discov, 9, 2019
5XKE
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CRYSTAL STRUCTURE OF T2R-TTL-DEMECOLCINE COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ...
Authors:Wang, Y., Yang, J., Wang, T., Chen, L.
Deposit date:2017-05-07
Release date:2018-07-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
To Be Published
5XKF
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CRYSTAL STRUCTURE OF T2R-TTL-MPC6827 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ...
Authors:Wang, Y., Yang, J., Wang, T., Chen, L.
Deposit date:2017-05-07
Release date:2018-04-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
To Be Published
5XKG
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CRYSTAL STRUCTURE OF T2R-TTL-CH1 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ...
Authors:Wang, Y., Yang, J., Wang, T., Chen, L.
Deposit date:2017-05-07
Release date:2018-04-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
To Be Published
5XKH
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CRYSTAL STRUCTURE OF T2R-TTL-CF1 COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ...
Authors:Wang, Y., Yang, J., Wang, T., Chen, L.
Deposit date:2017-05-07
Release date:2018-06-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Identification of a powerful and reversible microtubule-inhibitor with efficacy against multidrug-resistant tumors
To Be Published
3RY0
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CRYSTAL STRUCTURE OF TOMN, A 4-OXALOCROTONATE TAUTOMERASE HOMOLOGUE IN TOMAYMYCIN BIOSYNTHETIC PATHWAY
Descriptor:Putative tautomerase
Authors:Zhang, Y., Yan, W.P., Li, W.Z., Whitman, C.P.
Deposit date:2011-05-10
Release date:2011-08-17
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Kinetic, Crystallographic, and Mechanistic Characterization of TomN: Elucidation of a Function for a 4-Oxalocrotonate Tautomerase Homologue in the Tomaymycin Biosynthetic Pathway.
Biochemistry, 50, 2011
3OUH
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PHD2-R127 WITH JNJ41536014
Descriptor:Egl nine homolog 1, FE (II) ION, SULFATE ION, ...
Authors:Kim, H., Clark, R.
Deposit date:2010-09-14
Release date:2010-12-01
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
ACS Med Chem Lett, 1, 2010
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