5TSU

Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine

Summary for 5TSU

• Entry DOI: 10.2210/pdb5tsu/pdb
• Related: 5TT2
• Descriptor: Cystathionine gamma-lyase, METHIONINE, SULFATE ION, ... (7 entities in total)
• Functional Keywords: engineered protein, methioninase, inactive form, lyase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 373777.56

Authors

Yan, W.,Zhang, Y. (deposition date: 2016-10-31, release date: 2017-10-11, Last modification date: 2023-11-15)

• Primary citation: Yan, W.,Stone, E.,Zhang, Y.J.; Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.; Biochemistry, 56:876-885, 2017; PubMed: 28106980; DOI: 10.1021/acs.biochem.6b01172

Experimental method

X-RAY DIFFRACTION (2.2 Å)