5TSU
Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, D, F, G... | Cystathionine gamma-lyase | polymer | 422 | 46584.0 | 6 | UniProt (P32929) Pfam (PF01053) In PDB | Homo sapiens (Human) | Cysteine-protein sulfhydrase,Gamma-cystathionase |
2 | C, E | Cystathionine gamma-lyase | polymer | 422 | 46355.9 | 2 | UniProt (P32929) Pfam (PF01053) In PDB | Homo sapiens (Human) | Cysteine-protein sulfhydrase,Gamma-cystathionase |
3 | A | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) | |||
4 | A, B, D | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
5 | C, E | N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-methionine | non-polymer | 380.4 | 2 | Chemie (LPI) | |||
6 | F, G, H | CYSTEINE | non-polymer | 121.2 | 3 | Chemie (CYS) | |||
7 | water | water | 18.0 | 1012 | Chemie (HOH) |
Sequence modifications
A, B, D, F, G, H: 2 - 405 (UniProt: P32929)
C, E: 2 - 405 (UniProt: P32929)
PDB | External Database | Details |
---|---|---|
Met -16 | - | expression tag |
Gly -15 | - | expression tag |
Gly -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
Asn 59 | Glu 59 | engineered mutation |
Leu 119 | Arg 119 | engineered mutation |
Val 339 | Glu 339 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -16 | - | initiating methionine |
Gly -15 | - | expression tag |
Gly -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Glu -5 | - | expression tag |
Val -4 | - | expression tag |
Leu -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Pro 1 | - | expression tag |
Asn 59 | Glu 59 | engineered mutation |
Leu 119 | Arg 119 | engineered mutation |
Val 339 | Glu 339 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 372216.0 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 1561.6 | |
All* | Total formula weight | 373777.6 |