5TT2

Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine

Summary for 5TT2

• Entry DOI: 10.2210/pdb5tt2/pdb
• Descriptor: Cystathionine gamma-lyase, SULFATE ION (2 entities in total)
• Functional Keywords: engineered protein, methioninase, inactive form, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 93604.46

Authors

Yan, W.,Zhang, Y. (deposition date: 2016-10-31, release date: 2017-10-11, Last modification date: 2019-11-27)

• Primary citation: Yan, W.,Stone, E.,Zhang, Y.J.; Structural Snapshots of an Engineered Cystathionine-gamma-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.; Biochemistry, 56:876-885, 2017; PubMed: 28106980; DOI: 10.1021/acs.biochem.6b01172

Experimental method

X-RAY DIFFRACTION (2.949 Å)