5TT2

Inactive conformation of engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004123	molecular_function	cystathionine gamma-lyase activity
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006534	biological_process	cysteine metabolic process
C	0006629	biological_process	lipid metabolic process
C	0016829	molecular_function	lyase activity
C	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
C	0019343	biological_process	cysteine biosynthetic process via cystathionine
C	0019344	biological_process	cysteine biosynthetic process
C	0019346	biological_process	transsulfuration
C	0030170	molecular_function	pyridoxal phosphate binding
C	0030968	biological_process	endoplasmic reticulum unfolded protein response
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0044524	biological_process	protein sulfhydration
C	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
C	0047982	molecular_function	homocysteine desulfhydrase activity
C	0051289	biological_process	protein homotetramerization
C	0070062	cellular_component	extracellular exosome
C	0070814	biological_process	hydrogen sulfide biosynthetic process
C	0080146	molecular_function	L-cysteine desulfhydrase activity
C	0098606	molecular_function	selenocystathionine gamma-lyase activity
C	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
C	1990830	biological_process	cellular response to leukemia inhibitory factor
C	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0004123	molecular_function	cystathionine gamma-lyase activity
D	0005515	molecular_function	protein binding
D	0005516	molecular_function	calmodulin binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006534	biological_process	cysteine metabolic process
D	0006629	biological_process	lipid metabolic process
D	0016829	molecular_function	lyase activity
D	0018272	biological_process	protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
D	0019343	biological_process	cysteine biosynthetic process via cystathionine
D	0019344	biological_process	cysteine biosynthetic process
D	0019346	biological_process	transsulfuration
D	0030170	molecular_function	pyridoxal phosphate binding
D	0030968	biological_process	endoplasmic reticulum unfolded protein response
D	0042802	molecular_function	identical protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0044524	biological_process	protein sulfhydration
D	0044540	molecular_function	L-cystine L-cysteine-lyase (deaminating)
D	0047982	molecular_function	homocysteine desulfhydrase activity
D	0051289	biological_process	protein homotetramerization
D	0070062	cellular_component	extracellular exosome
D	0070814	biological_process	hydrogen sulfide biosynthetic process
D	0080146	molecular_function	L-cysteine desulfhydrase activity
D	0098606	molecular_function	selenocystathionine gamma-lyase activity
D	1904831	biological_process	positive regulation of aortic smooth muscle cell differentiation
D	1990830	biological_process	cellular response to leukemia inhibitory factor
D	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 C 501

Chain	Residue
C	ASN234
C	GLY235
C	ARG284
C	HIS288
C	GLY362
C	PHE363

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site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 C 502

Chain	Residue
C	THR179
C	ASN180
C	PRO181
C	THR182
C	ASP131
C	VAL132
C	TYR133

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site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 D 501

Chain	Residue
D	MET233
D	ASN234
D	GLY235
D	ARG284
D	HIS288
D	GLY362

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site_id	AC4
Number of Residues	8
Details	binding site for residue SO4 D 502

Chain	Residue
D	ASP131
D	VAL132
D	TYR133
D	THR179
D	ASN180
D	PRO181
D	THR182
D	LYS184

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Functional Information from PROSITE/UniProt

site_id	PS00868
Number of Residues	15
Details	CYS_MET_METAB_PP Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. DIsmySATKYMnGHS

Chain	Residue	Details
C	ASP223-SER237

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
C	ARG81
C	TYR133
C	LEU138
C	VAL358
D	ARG81
D	TYR133
D	LEU138
D	VAL358

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:19019829

Chain	Residue	Details
C	LLP231
D	LLP231

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