5EIG

Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine

Summary for 5EIG

• Entry DOI: 10.2210/pdb5eig/pdb
• Descriptor: Cystathionine gamma-lyase, SULFATE ION, CYSTEINE, ... (5 entities in total)
• Functional Keywords: cyst(e)inase, lyase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: P32929 P32929
• Total number of polymer chains: 8
• Total formula weight: 359406.76

Authors

Yan, W.,Zhang, J. (deposition date: 2015-10-29, release date: 2016-11-09, Last modification date: 2025-04-02)

• Primary citation: Cramer, S.,Saha, A.,Tadi, S.,Tiziani, S.,Yan, W.,Triplett, K.,Lamb, C.,Alters, S.,Johnson, D.,Zhang, Y.,DiGiovanni, J.,Georgiou, G.,Stone, E.; Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)