5EIG
Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, D, E, F... (A, C, D, E, F...) | Cystathionine gamma-lyase | polymer | 405 | 44850.2 | 6 | UniProt (P32929) Pfam (PF01053) | Homo sapiens (Human) | Cysteine-protein sulfhydrase,Gamma-cystathionase |
| 2 | B, H (B, H) | Cystathionine gamma-lyase | polymer | 405 | 44731.0 | 2 | UniProt (P32929) Pfam (PF01053) | Homo sapiens (Human) | Cysteine-protein sulfhydrase,Gamma-cystathionase |
| 3 | I, J, L, N, P (B, D, F, H) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | K, M, O (C, E, G) | CYSTEINE | non-polymer | 121.2 | 3 | Chemie (CYS) | |||
| 5 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 666 | Chemie (HOH) |
Sequence modifications
A, C, D, E, F, G: 1 - 405 (UniProt: P32929)
B, H: 1 - 405 (UniProt: P32929)
| PDB | External Database | Details |
|---|---|---|
| Thr 59 | Glu 59 | engineered mutation |
| Val 339 | Glu 339 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Thr 59 | Glu 59 | engineered mutation |
| Val 339 | Glu 339 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 358563.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 843.8 | |
| All* | Total formula weight | 359406.8 |
