6OVG

L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism

Summary for 6OVG

• Entry DOI: 10.2210/pdb6ovg/pdb
• Descriptor: Cystathionine gamma-lyase, SULFATE ION (3 entities in total)
• Functional Keywords: engineering, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 365920.44

Authors

Yan, W.,Irani, S.,Zhang, J. (deposition date: 2019-05-07, release date: 2020-04-22, Last modification date: 2023-11-15)

• Primary citation: Lu, W.C.,Saha, A.,Yan, W.,Garrison, K.,Lamb, C.,Pandey, R.,Irani, S.,Lodi, A.,Lu, X.,Tiziani, S.,Zhang, Y.J.,Georgiou, G.,DiGiovanni, J.,Stone, E.; Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.; Proc.Natl.Acad.Sci.USA, 117:13000-13011, 2020; PubMed: 32434918; DOI: 10.1073/pnas.1917362117

Experimental method

X-RAY DIFFRACTION (2.719 Å)