6OVG
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Cystathionine gamma-lyase | polymer | 415 | 45716.0 | 8 | UniProt (P32929) Pfam (PF01053) In PDB | Homo sapiens (Human) | Cysteine-protein sulfhydrase,Gamma-cystathionase |
2 | A, C | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
3 | water | water | 18.0 | 386 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 2 - 405 (UniProt: P32929)
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
Gly -8 | - | expression tag |
Gly -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Gly 0 | - | expression tag |
Gly 1 | - | expression tag |
Ile 59 | Glu 59 | conflict |
Leu 63 | Ser 63 | conflict |
Met 91 | Leu 91 | conflict |
Ala 119 | Arg 119 | conflict |
Arg 268 | Lys 268 | conflict |
Gly 311 | Thr 311 | conflict |
Val 339 | Glu 339 | conflict |
Ser 353 | Ile 353 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 365728.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 192.1 | |
All* | Total formula weight | 365920.4 |