6OVG

L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Cystathionine gamma-lyase	polymer	415	45716.0	8	UniProt (P32929) Pfam (PF01053)	Homo sapiens (Human)	Cysteine-protein sulfhydrase,Gamma-cystathionase
2	I, J (A, C)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	K, L, M, N, O... (A, B, C, D, E...)	water	water		18.0	386	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 2 - 405 (UniProt: P32929)

PDB	External Database	Details
Met -9	-	initiating methionine
Gly -8	-	expression tag
Gly -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Gly 0	-	expression tag
Gly 1	-	expression tag
Ile 59	Glu 59	conflict
Leu 63	Ser 63	conflict
Met 91	Leu 91	conflict
Ala 119	Arg 119	conflict
Arg 268	Lys 268	conflict
Gly 311	Thr 311	conflict
Val 339	Glu 339	conflict
Ser 353	Ile 353	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	365728.3
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	365920.4

*Water molecules are not included.