5V4E

Engineered human IgG Fc domain glyco801 (Fc801)

Summary for 5V4E

• Entry DOI: 10.2210/pdb5v4e/pdb
• Descriptor: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose, ... (10 entities in total)
• Functional Keywords: antibody engineering, fc fragment, igg, immune system
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : P01857
• Total number of polymer chains: 8
• Total formula weight: 211247.08

Authors

Yan, W.,Marshall, N.,Zhang, Y.J. (deposition date: 2017-03-09, release date: 2017-06-21, Last modification date: 2020-07-29)

• Primary citation: Lee, C.H.,Romain, G.,Yan, W.,Watanabe, M.,Charab, W.,Todorova, B.,Lee, J.,Triplett, K.,Donkor, M.,Lungu, O.I.,Lux, A.,Marshall, N.,Lindorfer, M.A.,Goff, O.R.,Balbino, B.,Kang, T.H.,Tanno, H.,Delidakis, G.,Alford, C.,Taylor, R.P.,Nimmerjahn, F.,Varadarajan, N.,Bruhns, P.,Zhang, Y.J.,Georgiou, G.; IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions.; Nat. Immunol., 18:889-898, 2017; PubMed: 28604720; DOI: 10.1038/ni.3770

Experimental method

X-RAY DIFFRACTION (3.216 Å)