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6WXQ
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BU of 6wxq by Molmil
Crystal structure of CRISPR-associated transcription factor Csa3 complexed with cA4
Descriptor: CRISPR-associated transcription factor Csa3 (Type I-A), GLYCEROL, cyclic tetraadenylate
Authors:Xia, P, Dutta, A, Parashar, V.
Deposit date:2020-05-11
Release date:2021-11-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of cyclic oligoadenylate binding to the transcription factor Csa3 outlines cross talk between type III and type I CRISPR systems.
J.Biol.Chem., 298, 2022
4QBW
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BU of 4qbw by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P.
Deposit date:2014-05-08
Release date:2015-02-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.912 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57, 2014
4QBE
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BU of 4qbe by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X.
Deposit date:2014-05-08
Release date:2014-12-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57C, 2014
4QAP
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BU of 4qap by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P.
Deposit date:2014-05-05
Release date:2015-02-11
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57, 2014
4QAH
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BU of 4qah by Molmil
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Bi, W.X.
Deposit date:2014-05-05
Release date:2014-12-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57C, 2014
4PV7
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BU of 4pv7 by Molmil
Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor
Descriptor: 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine, Dipeptidyl peptidase 4 soluble form
Authors:Xiao, P, Guo, R, Huang, S, Cui, H, Ye, S, Zhang, Z.
Deposit date:2014-03-15
Release date:2015-03-18
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold
Chin.Chem.Lett., 25, 2014
7WUQ
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BU of 7wuq by Molmil
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Descriptor: Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:He, Q.T, Guo, S.C, Xiao, P, Sun, J.P, Yu, X, Gou, L, Kong, L.L, Zhang, L.
Deposit date:2022-02-09
Release date:2022-04-27
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Nature, 604, 2022
7WUI
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BU of 7wui by Molmil
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Descriptor: Adhesion G-protein coupled receptor G2,mCherry, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Guo, S.C, He, Q.T, Xiao, P, Sun, J.P, Yu, X.
Deposit date:2022-02-08
Release date:2022-04-27
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Nature, 604, 2022
7WUJ
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BU of 7wuj by Molmil
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Descriptor: Adhesion G-protein coupled receptor G4,Uncharacterized protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Guo, S.C, Huang, S.M, He, Q.T, Xiao, P, Sun, J.P, Yu, X.
Deposit date:2022-02-08
Release date:2022-04-27
Last modified:2022-05-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4.
Nature, 604, 2022
2AYP
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BU of 2ayp by Molmil
Crystal Structure of CHK1 with an Indol Inhibitor
Descriptor: (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE, Serine/threonine-protein kinase Chk1
Authors:Lin, N.-H, Xia, P, Kovar, P, Chen, Z, Zhang, H, Rosenberg, S.H, Sham, H.L.
Deposit date:2005-09-07
Release date:2006-09-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors
Bioorg.Med.Chem.Lett., 16, 2006
8G59
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BU of 8g59 by Molmil
Cryo-EM structure of the TUG891 bound GPR120-Giq complex
Descriptor: 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-08
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.64 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
5J8R
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BU of 5j8r by Molmil
Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant
Descriptor: Tyrosine-protein phosphatase non-receptor type 12
Authors:Li, H, Yang, F, Xu, Y.F, Wang, W.J, Xiao, P, Yu, X, Sun, J.P.
Deposit date:2016-04-08
Release date:2016-04-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Crystal structure and substrate specificity of PTPN12.
Cell Rep, 15, 2016
4RAG
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BU of 4rag by Molmil
CRYSTAL STRUCTURE of PPC2A-D38K
Descriptor: MANGANESE (II) ION, Protein phosphatase 1A
Authors:Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P.
Deposit date:2014-09-10
Release date:2015-08-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The catalytic role of the M2 metal ion in PP2C alpha
Sci Rep, 5, 2015
4RAF
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BU of 4raf by Molmil
Crystal structure of PP2Ca-D38A
Descriptor: MANGANESE (II) ION, Protein phosphatase 1A
Authors:Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P.
Deposit date:2014-09-10
Release date:2015-08-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:The catalytic role of the M2 metal ion in PP2C alpha
Sci Rep, 5, 2015
7TS0
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BU of 7ts0 by Molmil
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric Go protein
Descriptor: Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Corticotropin-releasing factor receptor 2,Human corticotropin releasing factor receptor 2, Dominant negative Go alpha subunit, G protein gamma subunit, ...
Authors:Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E.
Deposit date:2022-01-31
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Nat Commun, 13, 2022
7TRY
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BU of 7try by Molmil
Cryo-EM structure of corticotropin releasing factor receptor 2 bound to Urocortin 1 and coupled with heterotrimeric G11 protein
Descriptor: Corticotropin-releasing factor receptor 2, G protein gamma subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhao, L.-H, Lin, J, Mao, C, Zhou, X.E, Ji, S, Shen, D, Xiao, P, Melcher, K, Zhang, Y, Yu, X, Xu, H.E.
Deposit date:2022-01-31
Release date:2022-11-09
Last modified:2022-11-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor.
Nat Commun, 13, 2022
4RA2
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BU of 4ra2 by Molmil
PP2Ca
Descriptor: MANGANESE (II) ION, PHOSPHATE ION, Protein phosphatase 1A
Authors:Pan, C, Tang, J.Y, Xu, Y.F, Xiao, P, Liu, H.D, Wang, H.A, Wang, W.B, Meng, F.G, Yu, X, Sun, J.P.
Deposit date:2014-09-09
Release date:2015-05-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:The catalytic role of the M2 metal ion in PP2Ca
SCI REP, 2015
8ID6
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BU of 8id6 by Molmil
Cryo-EM structure of the oleic acid bound GPR120-Gi complex
Descriptor: Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-15
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
8ID9
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BU of 8id9 by Molmil
Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex
Descriptor: 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-15
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
8ID4
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BU of 8id4 by Molmil
Cryo-EM structure of the linoleic acid bound GPR120-Gi complex
Descriptor: Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-15
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
8ID3
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BU of 8id3 by Molmil
Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex
Descriptor: 9-Hydroxyoctadecanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-15
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
8ID8
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BU of 8id8 by Molmil
Cryo-EM structure of the TUG891 bound GPR120-Gi complex
Descriptor: 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J.
Deposit date:2023-02-12
Release date:2023-03-15
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Unsaturated bond recognition leads to biased signal in a fatty acid receptor.
Science, 380, 2023
8IKJ
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BU of 8ikj by Molmil
Cryo-EM structure of the inactive CD97
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Adhesion G protein-coupled receptor E5,Soluble cytochrome b562,Adhesion G protein-coupled receptor E5 subunit beta
Authors:Mao, C, Zhao, R, Dong, Y, Gao, M, Chen, L, Zhang, C, Xiao, P, Guo, J, Qin, J, Shen, D, Ji, S, Zang, S, Zhang, H, Wang, W, Shen, Q, Sun, P, Zhang, Y.
Deposit date:2023-02-28
Release date:2024-02-14
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Conformational transitions and activation of the adhesion receptor CD97.
Mol.Cell, 84, 2024
7EPT
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BU of 7ept by Molmil
Structural basis for the tethered peptide activation of adhesion GPCRs
Descriptor: Adhesion G-protein coupled receptor D1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ping, Y.-Q, Xiao, P, Yang, F, Zhao, R.-J, Guo, S.-C, Yan, X, Wu, X, Liebscher, I, Xu, H.E, Sun, J.-P.
Deposit date:2021-04-27
Release date:2022-05-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for the tethered peptide activation of adhesion GPCRs.
Nature, 604, 2022
5ZO1
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BU of 5zo1 by Molmil
Crystal structure of mouse nectin-like molecule 4 (mNecl-4) full ectodomain (Ig1-Ig3), 2.2A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Cell adhesion molecule 4, GLYCEROL
Authors:Liu, X, An, T, Li, D, Fan, Z, Xiang, P, Li, C, Ju, W, Li, J, Hu, G, Qin, B, Yin, B, Wojdyla, J.A, Wang, M, Yuan, J, Qiang, B, Shu, P, Cui, S, Peng, X.
Deposit date:2018-04-12
Release date:2019-01-30
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structure of the heterophilic interaction between the nectin-like 4 and nectin-like 1 molecules.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019

 

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