The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop

Summary for 4QAH

Related4QAP 4QBE 4QBW
DescriptorTyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total)
Functional Keywordstyrosine phosphorylation, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side  P18031
Total number of polymer chains1
Total molecular weight34983.94
Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Bi, W.X. (deposition date: 2014-05-05, release date: 2014-12-24, Last modification date: 2018-02-07)
Primary citation
Xiao, P.,Wang, X.,Wang, H.M.,Fu, X.L.,Cui, F.A.,Yu, X.,Wen, S.S.,Bi, W.X.,Sun, J.P.
The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop
Int.J.Biochem.Cell Biol., 57C:84-95, 2014
PubMed: 25450460 (PDB entries with the same primary citation)
DOI: 10.1016/j.biocel.2014.10.004
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239152.4%5.3%7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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