4QAH
The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 1 | polymer | 299 | 34861.8 | 1 | UniProt (P18031) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase 1B, PTP-1B |
| 2 | B (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 3 | C (A) | water | water | 18.0 | 107 | Chemie (HOH) |
Sequence modifications
A: 1 - 299 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Lys 263 | Thr 263 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34861.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 122.1 | |
| All* | Total formula weight | 34983.9 |
