Author results

3FQ9
  • Download 3fq9
  • View 3fq9
Molmil generated image of 3fq9
DESIGN OF AN INSULIN ANALOG WITH ENHANCED RECEPTOR-BINDING SELECTIVITY. RATIONALE, STRUCTURE, AND THERAPEUTIC IMPLICATIONS
Descriptor:Insulin, ZINC ION
Authors:Zhao, M., Wan, Z.L., Whittaker, L., Xu, B., Phillips, N., Katsoyannis, P., Whittaker, J., Weiss, M.A.
Deposit date:2009-01-07
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
3JSD
  • Download 3jsd
  • View 3jsd
Molmil generated image of 3jsd
INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3ROV
  • Download 3rov
  • View 3rov
Molmil generated image of 3rov
INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1T1K
  • Download 1t1k
  • View 1t1k
Molmil generated image of 1t1k
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ALA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1P
  • Download 1t1p
  • View 1t1p
Molmil generated image of 1t1p
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-THR, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
1T1Q
  • Download 1t1q
  • View 1t1q
Molmil generated image of 1t1q
NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, VAL-B12-ABA, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:insulin, Insulin
Authors:Huang, K., Xu, B., Hu, S.Q., Chu, Y.C., Hua, Q.X., Whittaker, J., Nakagawa, S.H., De Meyts, P., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2004-04-16
Release date:2004-08-10
Last modified:2012-03-28
Method:SOLUTION NMR
Cite:How Insulin Binds: the B-Chain alpha-Helix Contacts the L1 beta-Helix of the Insulin Receptor.
J.Mol.Biol., 341, 2004
2JUM
  • Download 2jum
  • View 2jum
Molmil generated image of 2jum
THRA3-DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-08-31
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUU
  • Download 2juu
  • View 2juu
Molmil generated image of 2juu
ALLO-THRA3 DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-09-03
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUV
  • Download 2juv
  • View 2juv
Molmil generated image of 2juv
ABAA3-DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-09-05
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
4ZXB
  • Download 4zxb
  • View 4zxb
Molmil generated image of 4zxb
STRUCTURE OF THE HUMAN INSULIN RECEPTOR ECTODOMAIN, IRDELTABETA CONSTRUCT, IN COMPLEX WITH FOUR FAB MOLECULES
Descriptor:Fab 83-7 heavy chain, Fab 83-7 light chain, Fab 83-14 heavy chain, ...
Authors:Croll, T., Smith, B.J., Margetts, M.B., Whittaker, J., Weiss, M.A., Ward, C.W., Lawrence, M.C.
Deposit date:2015-05-20
Release date:2016-02-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure, 24, 2016
3KQ6
  • Download 3kq6
  • View 3kq6
Molmil generated image of 3kq6
ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
5KQV
  • Download 5kqv
  • View 5kqv
Molmil generated image of 5kqv
INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1,CR,L2, FNIII-1 AND ALPHACT PEPTIDE IN COMPLEX WITH BOVINE INSULIN AND FAB 83-14 (REVISED STRUCTURE)
Descriptor:Insulin, MONOCLONAL ANTIBODY FAB 83-14 - HEAVY CHAIN, MONOCLONAL ANTIBODY FAB 83-14 - LIGHT CHAIN, ...
Authors:Lawrence, M.C., Smith, B.J., Croll, T.I.
Deposit date:2016-07-06
Release date:2017-07-19
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:How insulin engages its primary binding site on the insulin receptor.
Nature, 493, 2013
3W11
  • Download 3w11
  • View 3w11
Molmil generated image of 3w11
INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HUMAN INSULIN, ALPHA-CT PEPTIDE(704-719) AND FAB 83-7
Descriptor:Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ...
Authors:Lawrence, M.C., Smith, B.J.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W12
  • Download 3w12
  • View 3w12
Molmil generated image of 3w12
INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HIGH-AFFINITY INSULIN ANALOGUE [D-PRO-B26]-DTI-NH2, ALPHA-CT PEPTIDE(704-719) AND FAB 83-7
Descriptor:Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ...
Authors:Lawrence, M.C., Smith, B.J., Brzozowsk, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (4.301 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
3W13
  • Download 3w13
  • View 3w13
Molmil generated image of 3w13
INSULIN RECEPTOR ECTODOMAIN CONSTRUCT COMPRISING DOMAINS L1-CR IN COMPLEX WITH HIGH-AFFINITY INSULIN ANALOGUE [D-PRO-B26]-DTI-NH2, ALPHACT PEPTIDE(693-719) AND FAB 83-7
Descriptor:Insulin receptor domains L1-CR, monoclonal antibody fab 83-7 fragment - heavy chain, monoclonal antibody fab 83-7 fragment - light chain, ...
Authors:Lawrence, M.C., Smith, B.J., Brzozowski, A.M.
Deposit date:2012-11-06
Release date:2013-01-09
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (4.303 Å)
Cite:How insulin engages its primary binding site on the insulin receptor
Nature, 493, 2013
2MLI
  • Download 2mli
  • View 2mli
Molmil generated image of 2mli
NMR STRUCTURE OF B25-(ALPHA, BETA)-DEHYDRO-PHENYLALANINE INSULIN
Descriptor:Insulin
Authors:Yang, Y., Weiss, M.
Deposit date:2014-02-27
Release date:2014-08-20
Last modified:2014-09-03
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
2MPI
  • Download 2mpi
  • View 2mpi
Molmil generated image of 2mpi
SOLUTION STRUCTURE OF B24G INSULIN
Descriptor:insulin chain A, insulin chain B
Authors:Yang, Y., Wickramasinghe, N.P., Hua, Q., Weiss, M.A.
Deposit date:2014-05-19
Release date:2014-12-24
Method:SOLUTION NMR
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NIB
  • Download 4nib
  • View 4nib
Molmil generated image of 4nib
CRYSTAL STRUCTURE OF HUMAN INSULIN MUTANT B20 D-ALA, B23 D-ALA
Descriptor:Insulin A chain, Insulin B chain
Authors:Menting, J.G., Lawrence, M.C.
Deposit date:2013-11-05
Release date:2014-08-27
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4OGA
  • Download 4oga
  • View 4oga
Molmil generated image of 4oga
INSULIN IN COMPLEX WITH SITE 1 OF THE HUMAN INSULIN RECEPTOR
Descriptor:Insulin A chain, Insulin B chain, monoclonal antibody fab 83-7 fragment - heavy chain, ...
Authors:Lawrence, M.C., Menting, J.G.
Deposit date:2014-01-15
Release date:2014-08-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111, 2014
4P65
  • Download 4p65
  • View 4p65
Molmil generated image of 4p65
CRYSTAL STRUCTURE OF AN CYCLOHEXYLALANINE SUBSTITUTED INSULIN ANALOG.
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Pandyarajan, V., Wan, Z., Weiss, M.A.
Deposit date:2014-03-21
Release date:2014-10-22
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289, 2014
2K91
  • Download 2k91
  • View 2k91
Molmil generated image of 2k91
ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-09-29
Release date:2008-11-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K9R
  • Download 2k9r
  • View 2k9r
Molmil generated image of 2k9r
ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-10-23
Release date:2008-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
5EMS
  • Download 5ems
  • View 5ems
Molmil generated image of 5ems
CRYSTAL STRUCTURE OF AN IODINATED INSULIN ANALOG
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Lawrence, M.C., Pandyarajan, V., Wan, Z., Weiss, M.A.
Deposit date:2015-11-06
Release date:2016-11-16
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.
J. Biol. Chem., 291, 2016
5WDM
  • Download 5wdm
  • View 5wdm
Molmil generated image of 5wdm
AN ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG RESISTS THERMAL INACTIVATION AND EXHIBITS BIOLOGICAL SIGNALING DURATION EQUIVALENT TO THE NATIVE PROTEIN
Descriptor:Single-chain insulin analog
Authors:Yee, V.C., Aldabbagh, K., Peng, Y.
Deposit date:2017-07-05
Release date:2017-11-15
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
J. Biol. Chem., 293, 2018
2L1Y
  • Download 2l1y
  • View 2l1y
Molmil generated image of 2l1y
NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Wan, Z.L., Hua, Q.X., Huang, K., Hu, S.Q., Philips, N.B., Katsoyannis, J.W., Weiss, M.A.
Deposit date:2010-08-09
Release date:2011-08-31
Method:SOLUTION NMR
Cite:Chiral Protein Engineering and its Application in G Health
To be Published
<12>