Author results

5GK3
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NATIVE STRUCTURE OF FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM ESCHERICHIA COLI AT 1.8 ANGSTROM RESOLUTION
Descriptor:Fructose-bisphosphate aldolase class 2, GLYCEROL, ZINC ION, ...
Authors:Tran, T.H., Huynh, K.H., Ho, T.H., Kang, L.W.
Deposit date:2016-07-03
Release date:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Apo structure of fructose 1,6-bisphosphate aldolase from Escherichia coli at 1.8 Angstrom resolution
To Be Published
5GK4
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NATIVE STRUCTURE OF FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM ESCHERICHIA COLI AT 2.0 ANGSTROM RESOLUTION
Descriptor:Fructose-bisphosphate aldolase class 2, GLYCEROL, ZINC ION, ...
Authors:Tran, T.H., Huynh, K.H., Ho, T.H., Kang, L.W.
Deposit date:2016-07-03
Release date:2017-07-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Apo structure of fructose 1,6-bisphosphate aldolase from Escherichia coli at 2.0 Angstrom resolution
To Be Published
5GK5
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APO STRUCTURE OF FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM ESCHERICHIA COLI AT 1.9 ANGSTROM RESOLUTION
Descriptor:Fructose-bisphosphate aldolase class 2, GLYCEROL, ZINC ION, ...
Authors:Tran, T.H., Huynh, K.H., Ho, T.H., Kang, L.W.
Deposit date:2016-07-03
Release date:2017-07-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Apo structure of fructose 1,6-bisphosphate aldolase from Escherichia coli at 1.9 angstrom resolution
To Be Published
5GK6
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STRUCTURE OF E.COLI FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE, CITRATE BOUND FORM
Descriptor:Fructose-bisphosphate aldolase class 2, ZINC ION, CITRIC ACID, ...
Authors:Tran, T.H., Huynh, K.H., Ho, T.H., Kang, L.W.
Deposit date:2016-07-03
Release date:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of E.Coli fructose 1,6-bisphosphate aldolase, Citrate bound form
To Be Published
5GK7
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STRUCTURE OF E.COLI FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE BOUND TO TRIS
Descriptor:Fructose-bisphosphate aldolase class 2, GLYCEROL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Tran, T.H., Huynh, K.H., Ho, T.H., Kang, L.W.
Deposit date:2016-07-03
Release date:2017-07-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of E.Coli fructose 1,6-bisphosphate aldolase, Tris bound form
To Be Published
5GK8
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STRUCTURE OF E.COLI FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE, ACETATE BOUND FORM
Descriptor:Fructose-bisphosphate aldolase class 2, GLYCEROL, ACETATE ION, ...
Authors:Tran, T.H., Huynh, K.H., Ho, T.H., Kang, L.W.
Deposit date:2016-07-03
Release date:2017-07-05
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structure of E.Coli fructose 1,6-bisphosphate aldolase, Acetate bound form
To Be Published
3QPB
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CRYSTAL STRUCTURE OF STREPTOCOCCUS PYOGENES URIDINE PHOSPHORYLASE REVEALS A SUBCLASS OF THE NP-I SUPERFAMILY
Descriptor:Uridine phosphorylase, RIBOSE-1-PHOSPHATE, URACIL
Authors:Tran, T.H., Christoffersen, S., Parker, W.B., Piskur, J., Serra, I., Terreni, M., Ealick, S.E.
Deposit date:2011-02-11
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The Crystal Structure of Streptococcus pyogenes Uridine Phosphorylase Reveals a Distinct Subfamily of Nucleoside Phosphorylases.
Biochemistry, 50, 2011
3RI6
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A NOVEL MECHANISM OF SULFUR TRANSFER CATALYZED BY O-ACETYLHOMOSERINE SULFHYDRYLASE IN METHIONINE BIOSYNTHETIC PATHWAY OF WOLINELLA SUCCINOGENES
Descriptor:O-ACETYLHOMOSERINE SULFHYDRYLASE
Authors:Tran, T.H., Krishnamoorthy, K., Begley, T.P., Ealick, S.E.
Deposit date:2011-04-13
Release date:2011-08-17
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes.
Acta Crystallogr.,Sect.D, 67, 2011
4RCN
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STRUCTURE AND FUNCTION OF A SINGLE-CHAIN, MULTI-DOMAIN LONG-CHAIN ACYL-COA CARBOXYLASE
Descriptor:long-chain acyl-CoA carboxylase
Authors:Tran, T.H., Tong, L.
Deposit date:2014-09-16
Release date:2014-11-05
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.
Nature, 518, 2015
5DTI
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CRYSTAL STRUCTURE OF MOUSE ACETYLCHOLINESTERASE
Descriptor:Acetylcholinesterase
Authors:Tran, T.H., Tong, L.
Deposit date:2015-09-18
Release date:2015-10-21
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.
Chembiochem, 16, 2015
5DTJ
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CRYSTAL STRUCTURE OF DFP-INHIBITED MOUSE ACETYLCHOLINESTERASE IN COMPLEX WITH THE REACTIVATOR SP-134
Descriptor:Acetylcholinesterase, 1-[5-(2,4-dichlorophenoxy)pentyl]-1H-imidazole
Authors:Tran, T.H., Tong, L.
Deposit date:2015-09-18
Release date:2015-10-21
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.
Chembiochem, 16, 2015
5HCU
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CRYSTAL STRUCTURE OF MOUSE ACETYLCHOINESTERASE INHIBITED BY DFP
Descriptor:Acetylcholinesterase
Authors:Tran, T.H., Tong, L.
Deposit date:2016-01-04
Release date:2016-01-20
Method:X-RAY DIFFRACTION (2.4151 Å)
Cite:Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.
Chembiochem, 16, 2015
6CU6
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CRYSTAL STRUCTURE OF GMPPNP-BOUND G12R MUTANT OF HUMAN KRAS4B
Descriptor:GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tran, T.H., Simanshu, D.K.
Deposit date:2018-03-23
Release date:2019-09-25
Last modified:2020-01-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Atypical KRASG12RMutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
Cancer Discov, 10, 2020
6OB2
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CRYSTAL STRUCTURE OF WILD-TYPE KRAS (GMPPNP-BOUND) IN COMPLEX WITH GAP-RELATED DOMAIN (GRD) OF NEUROFIBROMIN (NF1)
Descriptor:GTPase KRas, Neurofibromin, GLYCEROL, ...
Authors:Tran, T.H., Dharmaiah, S., Simanshu, D.K.
Deposit date:2019-03-19
Release date:2019-10-16
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.845 Å)
Cite:KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
Proc.Natl.Acad.Sci.USA, 116, 2019
6OB3
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CRYSTAL STRUCTURE OF G13D-KRAS (GMPPNP-BOUND) IN COMPLEX WITH GAP-RELATED DOMAIN (GRD) OF NEUROFIBROMIN (NF1)
Descriptor:GTPase KRas, Neurofibromin, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tran, T.H., Dharmaiah, S., Simanshu, D.K.
Deposit date:2019-03-19
Release date:2019-10-16
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
Proc.Natl.Acad.Sci.USA, 116, 2019
6P4Z
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STRUCTURE OF GADOLINIUM-CAGED COBALT (III) INSULIN HEXAMER
Descriptor:Insulin chain A, Insulin chain B, COBALT (II) ION, ...
Authors:Tran, T.H., Taylor, S.K., Stojanovic, M.N., Tong, L.
Deposit date:2019-05-29
Release date:2019-06-12
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore
ChemBioChem, 24, 2018
4FLO
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CRYSTAL STRUCTURE OF AMYLOSUCRASE DOUBLE MUTANT A289P-F290C FROM NEISSERIA POLYSACCHAREA
Descriptor:Amylosucrase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ...
Authors:Guerin, F., Champion, E., Moulis, C., Barbe, S., Tran, T.H., Morel, S., Descroix, K., Monsan, P., Mulard, L.A., Remaud-Simeon, M., Andre, I., Mourey, L., Tranier, S.
Deposit date:2012-06-15
Release date:2012-10-31
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Applying pairwise combinations of amino Acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides.
J.Am.Chem.Soc., 134, 2012
4FLQ
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CRYSTAL STRUCTURE OF AMYLOSUCRASE DOUBLE MUTANT A289P-F290I FROM NEISSERIA POLYSACCHAREA.
Descriptor:Amylosucrase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ...
Authors:Guerin, F., Champion, E., Moulis, C., Barbe, S., Tran, T.H., Morel, S., Descroix, K., Monsan, P., Mulard, L.A., Remaud-Simeon, M., Andre, I., Mourey, L., Tranier, S.
Deposit date:2012-06-15
Release date:2012-10-31
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Applying pairwise combinations of amino Acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides.
J.Am.Chem.Soc., 134, 2012
4FLR
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CRYSTAL STRUCTURE OF AMYLOSUCRASE DOUBLE MUTANT A289P-F290L FROM NEISSERIA POLYSACCHAREA
Descriptor:Amylosucrase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ...
Authors:Guerin, F., Champion, E., Moulis, C., Barbe, S., Tran, T.H., Morel, S., Descroix, K., Monsan, P., Mulard, L.A., Remaud-Simeon, M., Andre, I., Mourey, L., Tranier, S.
Deposit date:2012-06-15
Release date:2012-10-31
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Applying pairwise combinations of amino Acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides.
J.Am.Chem.Soc., 134, 2012
4FLS
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CRYSTAL STRUCTURE OF AMYLOSUCRASE INACTIVE DOUBLE MUTANT F290K-E328Q FROM NEISSERIA POLYSACCHAREA IN COMPLEX WITH SUCROSE.
Descriptor:Amylosucrase, SUCROSE, CHLORIDE ION, ...
Authors:Guerin, F., Champion, E., Moulis, C., Barbe, S., Tran, T.H., Morel, S., Descroix, K., Monsan, P., Mulard, L.A., Remaud-Simeon, M., Andre, I., Mourey, L., Tranier, S.
Deposit date:2012-06-15
Release date:2012-10-31
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Applying pairwise combinations of amino Acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides.
J.Am.Chem.Soc., 134, 2012
4KS9
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CRYSTAL STRUCTURE OF MALONYL-COA DECARBOXYLASE (RMET_2797) FROM CUPRIAVIDUS METALLIDURANS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET CRR76
Descriptor:Malonyl-CoA decarboxylase, MAGNESIUM ION
Authors:Forouhar, F., Tran, T.H., Lew, S., Seetharaman, J., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2013-05-17
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of malonyl-coenzyme a decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.
Structure, 21, 2013
5TAR
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CRYSTAL STRUCTURE OF FARNESYLATED AND METHYLATED KRAS4B IN COMPLEX WITH PDE-DELTA (CRYSTAL FORM II - WITH ORDERED HYPERVARIABLE REGION)
Descriptor:GTPase KRas, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, FARNESYL, ...
Authors:Dharmaiah, S., Tran, T.H., Simanshu, D.K.
Deposit date:2016-09-10
Release date:2016-11-02
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
Proc.Natl.Acad.Sci.USA, 113, 2016
5TB5
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CRYSTAL STRUCTURE OF FULL-LENGTH FARNESYLATED AND METHYLATED KRAS4B IN COMPLEX WITH PDE-DELTA (CRYSTAL FORM I - WITH PARTIALLY DISORDERED HYPERVARIABLE REGION)
Descriptor:GTPase KRas, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, FARNESYL, ...
Authors:Dharmaiah, S., Tran, T.H., Simanshu, D.K.
Deposit date:2016-09-11
Release date:2016-11-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of recognition of farnesylated and methylated KRAS4b by PDE delta.
Proc.Natl.Acad.Sci.USA, 113, 2016
6M9W
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STRUCTURE OF MG-FREE KRAS4B (2-169) BOUND TO GDP WITH THE SWITCH-I IN FULLY OPEN CONFORMATION
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE
Authors:Dharmaiah, S., Tran, T.H., Yan, W., Simanshu, D.K.
Deposit date:2018-08-24
Release date:2019-07-31
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
6MBT
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CRYSTAL STRUCTURE OF WILD-TYPE KRAS BOUND TO GDP AND MG (SPACE GROUP C2)
Descriptor:GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Dharmaiah, S., Tran, T.H., Yan, W., Simanshu, D.K.
Deposit date:2018-08-30
Release date:2019-07-31
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.
Sci Rep, 9, 2019
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