6WS2

Crystal structure of KRAS-K104Q mutant, GDP-bound

Summary for 6WS2

Entry DOI	10.2210/pdb6ws2/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	kras, ras, mg, k-ras, small gtpase, guanine nucleotide, oncoprotein, gmppnp, gppnhp, k104, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	79888.96
Authors	Tran, T.H.,Simanshu, D.K. (deposition date: 2020-04-30, release date: 2021-11-10, Last modification date: 2023-10-18)
Primary citation	Yang, M.H.,Tran, T.H.,Hunt, B.,Agnor, R.,Johnson, C.W.,Shui, B.,Waybright, T.J.,Nowak, J.A.,Stephen, A.G.,Simanshu, D.K.,Haigis, K.M. Allosteric regulation of switch-II domain controls KRAS oncogenicity. Cancer Res., 2023 Cited by PubMed: 37556505 DOI: 10.1158/0008-5472.CAN-22-3210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.59 Å)

Structure validation