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1FQ9
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BU of 1fq9 by Molmil
CRYSTAL STRUCTURE OF A TERNARY FGF2-FGFR1-HEPARIN COMPLEX
Descriptor: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-beta-L-altropyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 2, ...
Authors:Schlessinger, J, Plotnikov, A.N, Ibrahimi, O.A, Eliseenkova, A.V, Yeh, B.K, Yayon, A, Linhardt, R.J, Mohammadi, M.
Deposit date:2000-09-04
Release date:2000-09-27
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Mol.Cell, 6, 2000
2AXM
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BU of 2axm by Molmil
HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR
Authors:Digabriele, A.D, Lax, I, Chen, D.I, Svahn, C.M, Jaye, M, Schlessinger, J, Hendrickson, W.A.
Deposit date:1997-10-20
Release date:1998-04-22
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
3KVQ
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BU of 3kvq by Molmil
Crystal structure of VEGFR2 extracellular domain D7
Descriptor: Vascular endothelial growth factor receptor 2
Authors:Yang, Y, Opatowsky, Y, Xie, P, Schlessinger, J.
Deposit date:2009-11-30
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Proc.Natl.Acad.Sci.USA, 107, 2010
6NFJ
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BU of 6nfj by Molmil
Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide
Descriptor: Beta-klotho, Fibroblast growth factor 19, Nanobody 30
Authors:Kuzina, E, Schlessinger, J, Lee, S.
Deposit date:2018-12-20
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8DFM
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BU of 8dfm by Molmil
Ectodomain of full-length wild-type KIT-SCF dimers
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ...
Authors:Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J.
Deposit date:2022-06-22
Release date:2023-03-29
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DFQ
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BU of 8dfq by Molmil
Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ...
Authors:Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J.
Deposit date:2022-06-22
Release date:2023-03-29
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DFP
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BU of 8dfp by Molmil
Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ...
Authors:Bertoletti, N, Krimmer, S.G, Mi, W, Schlessinger, J.
Deposit date:2022-06-22
Release date:2023-03-29
Last modified:2023-04-05
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
5CUS
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BU of 5cus by Molmil
Crystal Structure of sErbB3-Fab3379 Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab LC region of KTN3379, IgG H chain, ...
Authors:Lee, S, Schlessinger, J.
Deposit date:2015-07-25
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration.
Proc.Natl.Acad.Sci.USA, 112, 2015
6M9H
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BU of 6m9h by Molmil
JAK2 JH2 in complex with diaminopyrimidine JAK040
Descriptor: 4-({4-amino-6-[4-(2-hydroxyethyl)-1H-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrile, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Puleo, D.E, Schlessinger, J, Jorgensen, W.L.
Deposit date:2018-08-23
Release date:2018-09-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:JAK2 JH2 Binders
To Be Published
4PGZ
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BU of 4pgz by Molmil
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit
Authors:Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
Deposit date:2014-05-03
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015
3KXX
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BU of 3kxx by Molmil
Structure of the mutant Fibroblast Growth Factor receptor 1
Descriptor: Basic fibroblast growth factor receptor 1
Authors:Bae, J.H, Boggon, T.J, Tome, F, Mandiyan, V, Lax, I, Schlessinger, J.
Deposit date:2009-12-04
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KY2
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BU of 3ky2 by Molmil
Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain
Descriptor: Basic fibroblast growth factor receptor 1, SULFATE ION
Authors:Bae, J.H, Boggon, T.J, Tome, F, Mandiyan, V, Lax, I, Schlessinger, J.
Deposit date:2009-12-04
Release date:2010-03-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
1AGW
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BU of 1agw by Molmil
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Descriptor: 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE, FGF RECEPTOR 1
Authors:Mohammadi, M, Schlessinger, J, Hubbard, S.R.
Deposit date:1997-03-25
Release date:1998-03-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
7JYO
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BU of 7jyo by Molmil
JAK2 JH2 in complex with JAK064
Descriptor: 3-({4-amino-6-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl}oxy)benzoic acid, GLYCEROL, Tyrosine-protein kinase JAK2
Authors:Puleo, D.E, Krimmer, S.G, Newton, A.S, Schlessinger, J, Jorgensen, W.L.
Deposit date:2020-08-31
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.16127229 Å)
Cite:Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant
Tetrahedron Lett., 77, 2021
7JYQ
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BU of 7jyq by Molmil
JAK2 JH2 in complex with JAK020
Descriptor: GLYCEROL, N~2~-(4-fluorophenyl)-6-{[(5-{[(oxolan-2-yl)methyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]methyl}-1,3,5-triazine-2,4-diamine, Tyrosine-protein kinase JAK2
Authors:Puleo, D.E, Krimmer, S.G, Newton, A.S, Schlessinger, J, Jorgensen, W.L.
Deposit date:2020-08-31
Release date:2021-07-14
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85941613 Å)
Cite:Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant
Tetrahedron Lett., 77, 2021
2FGI
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BU of 2fgi by Molmil
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FGF RECEPTOR 1 IN COMPLEX WITH INHIBITOR PD173074
Descriptor: 1-TERT-BUTYL-3-[6-(3,5-DIMETHOXY-PHENYL)-2-(4-DIETHYLAMINO-BUTYLAMINO)-PYRIDO[2,3-D]PYRIMIDIN-7-YL]-UREA, PROTEIN (FIBROBLAST GROWTH FACTOR (FGF) RECEPTOR 1)
Authors:Mohammadi, M, Froum, S, Hamby, J.M, Schroeder, M, Panek, R.L, Lu, G.H, Eliseenkova, A.V, Green, D, Schlessinger, J, Hubbard, S.R.
Deposit date:1998-09-15
Release date:1999-09-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.
EMBO J., 17, 1998
1MAI
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BU of 1mai by Molmil
STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE
Descriptor: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, PHOSPHOLIPASE C DELTA-1
Authors:Ferguson, K.M, Lemmon, M.A, Schlessinger, J, Sigler, P.B.
Deposit date:1996-05-23
Release date:1996-11-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain.
Cell(Cambridge,Mass.), 83, 1995
4K9E
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BU of 4k9e by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor Kit, heavy chain, ...
Authors:Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
Deposit date:2013-04-19
Release date:2013-10-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
3B2T
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BU of 3b2t by Molmil
Structure of phosphotransferase
Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(methyl)phosphoryl]oxy}phosphoryl]adenosine, Fibroblast growth factor receptor 2, PHOSPHATE ION
Authors:Lew, E.D, Bae, J.H, Rohmann, E, Wollnik, B, Schlessinger, J.
Deposit date:2007-10-19
Release date:2008-02-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2E9W
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BU of 2e9w by Molmil
Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Kit ligand, Mast/stem cell growth factor receptor
Authors:Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J.
Deposit date:2007-01-27
Release date:2007-08-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
4K94
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BU of 4k94 by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab19 heavy chain, Fab19 light chain, ...
Authors:Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
Deposit date:2013-04-19
Release date:2013-10-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
2EC8
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BU of 2ec8 by Molmil
Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor
Authors:Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J.
Deposit date:2007-02-11
Release date:2007-08-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
6BSS
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BU of 6bss by Molmil
JAK2 JH2 in complex with NU6102
Descriptor: GLYCEROL, O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE, Tyrosine-protein kinase JAK2
Authors:Puleo, D.E, Schlessinger, J.
Deposit date:2017-12-04
Release date:2018-08-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:JAK2 JH2 Binders
To Be Published
6BRW
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BU of 6brw by Molmil
JAK2 JH2 in complex with XMU-MP-1
Descriptor: 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide, ACETATE ION, GLYCEROL, ...
Authors:Puleo, D.E, Schlessinger, J.
Deposit date:2017-12-01
Release date:2018-08-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.031 Å)
Cite:JAK2 JH2 Binders
To Be Published
6BS0
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BU of 6bs0 by Molmil
JAK2 JH2 in complex with 63552444
Descriptor: 4-(5-aminopyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine, GLYCEROL, Tyrosine-protein kinase JAK2
Authors:Puleo, D.E, Schlessinger, J.
Deposit date:2017-12-01
Release date:2018-08-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.541 Å)
Cite:JAK2 JH2 Binders
To Be Published

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