3KVQ

Crystal structure of VEGFR2 extracellular domain D7

Summary for 3KVQ

DescriptorVascular endothelial growth factor receptor 2 (2 entities in total)
Functional Keywordsvegfr2, angiogenesis, atp-binding, developmental protein, differentiation, glycoprotein, host-virus interaction, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P35968
Total number of polymer chains1
Total molecular weight11912.4
Authors
Yang, Y.,Opatowsky, Y.,Xie, P.,Schlessinger, J. (deposition date: 2009-11-30, release date: 2010-02-16, Last modification date: 2011-07-13)
Primary citation
Yang, Y.,Xie, P.,Opatowsky, Y.,Schlessinger, J.
Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
Proc.Natl.Acad.Sci.USA, 107:1906-1911, 2010
PubMed: 20080685 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0914052107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.290212.6%11.3%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution