5CUS

Crystal Structure of sErbB3-Fab3379 Complex

Summary for 5CUS

Entry DOI	10.2210/pdb5cus/pdb
Descriptor	Receptor tyrosine-protein kinase erbB-3, IgG H chain, Fab LC region of KTN3379, ... (4 entities in total)
Functional Keywords	erbb3, antibody, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	463640.20
Authors	Lee, S.,Schlessinger, J. (deposition date: 2015-07-25, release date: 2015-10-14, Last modification date: 2023-09-27)
Primary citation	Lee, S.,Greenlee, E.B.,Amick, J.R.,Ligon, G.F.,Lillquist, J.S.,Natoli, E.J.,Hadari, Y.,Alvarado, D.,Schlessinger, J. Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration. Proc.Natl.Acad.Sci.USA, 112:13225-13230, 2015 Cited by PubMed: 26460020 DOI: 10.1073/pnas.1518361112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation