5CUS
Crystal Structure of sErbB3-Fab3379 Complex
Summary for 5CUS
Entry DOI | 10.2210/pdb5cus/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-3, IgG H chain, Fab LC region of KTN3379, ... (4 entities in total) |
Functional Keywords | erbb3, antibody, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 463640.20 |
Authors | Lee, S.,Schlessinger, J. (deposition date: 2015-07-25, release date: 2015-10-14, Last modification date: 2023-09-27) |
Primary citation | Lee, S.,Greenlee, E.B.,Amick, J.R.,Ligon, G.F.,Lillquist, J.S.,Natoli, E.J.,Hadari, Y.,Alvarado, D.,Schlessinger, J. Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration. Proc.Natl.Acad.Sci.USA, 112:13225-13230, 2015 Cited by PubMed: 26460020DOI: 10.1073/pnas.1518361112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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