5CUS

Crystal Structure of sErbB3-Fab3379 Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Receptor tyrosine-protein kinase erbB-3	polymer	627	69219.5	4	UniProt (P21860) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (Human)	Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3
2	E, G, H, I (H, I, J, K)	IgG H chain	polymer	221	23351.2	4	UniProt (S6B291) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
3	F, J, K, L (L, M, N, O)	Fab LC region of KTN3379	polymer	216	22731.1	4		Homo sapiens
4	M, N, O, P, Q... (A, B, C, D, M)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	11	Chemie (NAG)

Sequence modifications

A, B, C, D: 1 - 622 (UniProt: P21860)

PDB	External Database	Details
His 623	-	expression tag
His 624	-	expression tag
His 625	-	expression tag
His 626	-	expression tag
His 627	-	expression tag

H, I, J, K: 1 - 221 (UniProt: S6B291)

PDB	External Database	Details
Gly 10	Asp 29	conflict
Tyr 31	Thr 50	conflict
Tyr 33	Ala 52	conflict
Gln 35	Ser 54	conflict
Tyr 50	Gly 69	conflict
Ser 53	Asp 72	conflict
Gly 56	His 75	conflict
Val 57	Ser 76	conflict
Thr 58	Ile 77	conflict
Asn 59	Tyr 78	conflict
Arg 98	-	insertion
Val 99	Thr 117	conflict
Leu 101	Ser 119	conflict
Gly 102	Gln 120	conflict
Asp 103	Trp 121	conflict
Ala 104	Pro 122	conflict
Phe 105	Gly 123	conflict
Ile 107	Tyr 125	conflict
Met 113	Leu 131	conflict
Lys 215	Arg 233	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	461206.9
Non-Polymers*	Number of molecules	11
	Total formula weight	2433.3
All*	Total formula weight	463640.2

*Water molecules are not included.