3B2T

Structure of phosphotransferase

Summary for 3B2T

• Entry DOI: 10.2210/pdb3b2t/pdb
• Descriptor: Fibroblast growth factor receptor 2, PHOSPHATE ION, 5'-O-[(S)-hydroxy{[(S)-hydroxy(methyl)phosphoryl]oxy}phosphoryl]adenosine, ... (4 entities in total)
• Functional Keywords: phosphotransferase, cell signaling, alternative splicing, atp-binding, disease mutation, ectodermal dysplasia, glycoprotein, heparin-binding, immunoglobulin domain, kinase, lacrimo-auriculo-dento-digital syndrome, membrane, nucleotide-binding, phosphorylation, polymorphism, receptor, secreted, transmembrane, tyrosine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted: P21802
• Total number of polymer chains: 2
• Total formula weight: 72530.58

Authors

Lew, E.D.,Bae, J.H.,Rohmann, E.,Wollnik, B.,Schlessinger, J. (deposition date: 2007-10-19, release date: 2008-02-26, Last modification date: 2023-08-30)

• Primary citation: Lew, E.D.,Bae, J.H.,Rohmann, E.,Wollnik, B.,Schlessinger, J.; Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation.; Proc.Natl.Acad.Sci.Usa, 104:19802-19807, 2007; PubMed: 18056630; DOI: 10.1073/pnas.0709905104

Experimental method

X-RAY DIFFRACTION (1.8 Å)