Author results

4COS
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CRYSTAL STRUCTURE OF THE PHD-BROMO-PWWP CASSETTE OF HUMAN PRKCBP1
Descriptor:PROTEIN KINASE C-BINDING PROTEIN 1, ZINC ION, 1,4-DIETHYLENE DIOXIDE
Authors:Krojer, T., Savitsky, P., Newman, J.A., Cooper, C.D.O., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Filippakopoulos, P.
Deposit date:2014-01-30
Release date:2014-03-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.
Cell Rep, 17, 2016
2XIK
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STRUCTURE OF HUMAN YSK1 (YEAST SPS1-STE20-RELATED KINASE 1)
Descriptor:SERINE/THREONINE PROTEIN KINASE 25, 1,2-ETHANEDIOL, 5-[(E)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-[2-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Authors:Muniz, J.R.C., Rellos, P., Ugochukwu, E., Vollmar, M., Allerston, C., Chaikuad, A., Savitsky, P., Berridge, G., Brenner, B., Elkins, J.M., Daga, N., Gileadi, O., Mahajan, P., Shrestha, B., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2010-06-30
Release date:2010-07-14
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structure of Human Ysk1 (Yeast Sps1-Ste20-Related Kinase 1)
To be Published
3MTL
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CRYSTAL STRUCTURE OF THE PCTAIRE1 KINASE IN COMPLEX WITH INDIRUBIN E804
Descriptor:Cell division protein kinase 16, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
to be published
3NR9
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STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)
Descriptor:Dual specificity protein kinase CLK2, (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one
Authors:Chaikuad, A., Savitsky, P., Krojer, T., Muniz, J.R.C., Filippakopoulos, P., Rellos, P., Keates, T., Fedorov, O., Pike, A.C.W., Eswaran, J., Berridge, G., Phillips, C., Zhang, Y., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2010-06-30
Release date:2010-08-25
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structure of human CDC2-like kinase 2 (CLK2)
To be Published
4FR4
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CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE-PROTEIN KINASE 32A (YANK1)
Descriptor:Serine/threonine-protein kinase 32A, STAUROSPORINE, 1,2-ETHANEDIOL
Authors:Chaikuad, A., Elkins, J.M., Krojer, T., Mahajan, P., Goubin, S., Szklarz, M., Tumber, A., Wang, J., Savitsky, P., Shrestha, B., Daga, N., Picaud, S., Fedorov, O., Allerston, C.K., Latwiel, S.V.A., Vollmar, M., Canning, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2012-06-26
Release date:2012-07-18
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal structure of human serine/threonine-protein kinase 32A (YANK1)
To be Published
4PY6
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CRYSTAL STRUCTURE OF BROMODOMAIN OF PFA0510W FROM PLASMODIUM FALCIPARUM
Descriptor:Bromodomain protein, putative, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, ...
Authors:Fonseca, M., Tallant, C., Hutchinson, A., Savitsky, P., Krojer, T., Filippakopoulos, P., Loppnau, P., Brennan, P.E., von Delft, F., Dong, A., Josling, G.A., Duffy, M.F., Arrowsmith, C.H., Bountra, C., Hui, R., Knapp, S., Wernimont, A.K., Structural Genomics Consortium (SGC)
Deposit date:2014-03-26
Release date:2014-04-30
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of bromodomain of PFA0510w from Plasmodium Falciparum
To be Published
3GVU
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THE CRYSTAL STRUCTURE OF HUMAN ABL2 IN COMPLEX WITH GLEEVEC
Descriptor:Tyrosine-protein kinase ABL2, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
Authors:Ugochukwu, E., Salah, E., Barr, A., Mahajan, P., Shrestha, B., Savitsky, P., Chaikuad, A., Filippakopoulos, P., Roos, A., Pike, A.C.W., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-03-31
Release date:2009-04-21
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The crystal structure of human ABL2 in complex with GLEEVEC
To be Published
2C9Y
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STRUCTURE OF HUMAN ADENYLATE KINASE 2
Descriptor:ADENYLATE KINASE ISOENZYME 2, MITOCHONDRIAL, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ...
Authors:Bunkoczi, G., Filippakopoulos, P., Debreczeni, J.E., Turnbull, A., Papagrigoriou, E., Savitsky, P., Colebrook, S., von Delft, F., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S.
Deposit date:2005-12-15
Release date:2006-01-04
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of Human Adenylate Kinase 2
To be Published
2CHL
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STRUCTURE OF CASEIN KINASE 1 GAMMA 3
Descriptor:CASEIN KINASE I ISOFORM GAMMA-3, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, SULFATE ION
Authors:Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Ugochukwu, E., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-03-15
Release date:2006-03-22
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of Casein Kinase 1 Gamma 3
To be Published
2CMW
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STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITH 2-(2- HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
Descriptor:CASEIN KINASE I ISOFORM GAMMA-1, 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE, PHOSPHATE ION, ...
Authors:Bunkoczi, G., Rellos, P., Das, S., Savitsky, P., Niesen, F., Sobott, F., Fedorov, O., Pike, A.C.W., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Weigelt, J., Knapp, S.
Deposit date:2006-05-15
Release date:2006-06-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure of Human Casein Kinase 1 Gamma-1 in Complex with 2-(2-Hydroxyethylamino)-6-(3-Chloroanilino)-9-Isopropylpurine (Casp Target)
To be Published
2I6L
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CRYSTAL STRUCTURE OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE 6 (MAPK6)
Descriptor:Mitogen-activated protein kinase 6
Authors:Filippakopoulos, P., Turnbull, A.P., Savitsky, P., Fedorov, O., Berridge, G., Das, S., Elkins, J., Soundararajan, M., Yang, X.W., Doyle, D., Papagrigoriou, E., Pike, A.C.W., Bunkonczi, G., Ugochukwu, E., Debreczeni, J., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-08-29
Release date:2006-09-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of the Human Mitogen Activated Protein Kinase 6
To be Published
2IZR
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
Descriptor:CASEIN KINASE I ISOFORM GAMMA-3, {(2Z)-4-AMINO-2-[(4-METHOXYPHENYL)IMINO]-2,3-DIHYDRO-1,3-THIAZOL-5-YL}(4-METHOXYPHENYL)METHANONE, MAGNESIUM ION, ...
Authors:Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-07-26
Release date:2006-08-01
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Inhibitor Binding by Casein Kinases
To be Published
2IZS
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
Descriptor:CASEIN KINASE I ISOFORM GAMMA-3, {[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE, MAGNESIUM ION, ...
Authors:Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-07-26
Release date:2006-08-01
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Inhibitor Binding by Casein Kinases
To be Published
2IZT
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
Descriptor:CASEIN KINASE I ISOFORM GAMMA-3, N2-[(1R,2S)-2-AMINOCYCLOHEXYL]-N6-(3-CHLOROPHENYL)-9-ETHYL-9H-PURINE-2,6-DIAMINE, CHLORIDE ION
Authors:Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-07-26
Release date:2006-08-01
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitor Binding by Casein Kinases
To be Published
2IZU
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STRUCTURE OF CASEIN KINASE GAMMA 3 IN COMPLEX WITH INHIBITOR
Descriptor:CASEIN KINASE I ISOFORM GAMMA-3, 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, 1,2-ETHANEDIOL, ...
Authors:Bunkoczi, G., Salah, E., Rellos, P., Das, S., Fedorov, O., Savitsky, P., Debreczeni, J.E., Gileadi, O., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-07-26
Release date:2006-08-01
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Inhibitor Binding by Casein Kinases
To be Published
2JJD
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PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, E ISOFORM
Descriptor:RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON, CHLORIDE ION
Authors:Elkins, J.M., Ugochukwu, E., Alfano, I., Barr, A.J., Bunkoczi, G., King, O.N.F., Filippakopoulos, P., Savitsky, P., Salah, E., Pike, A., Johansson, C., Das, S., Burgess-Brown, N.A., Gileadi, O., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Knapp, S.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2012-06-06
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome.
Cell(Cambridge,Mass.), 136, 2009
2JK9
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THE STRUCTURE OF SPLA-RYANODINE RECEPTOR DOMAIN AND SOCS BOX CONTAINING 1 IN COMPLEX WITH A PAR-4 PEPTIDE
Descriptor:SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1, PRKC APOPTOSIS WT1 REGULATOR PROTEIN
Authors:Filippakopoulos, P., Bullock, A., Keates, T., Savitsky, P., Murray, J.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wickstroem, M., Bountra, C., Knapp, S.
Deposit date:2008-08-22
Release date:2008-09-16
Last modified:2012-12-05
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Basis for Par-4 Recognition by the Spry Domain-and Socs Box-Containing Proteins Spsb1, Spsb2, and Spsb4.
J.Mol.Biol., 401, 2010
2O2V
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CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN MITOGEN ACTIVATED PROTEIN KINASE KINASE 5 PHOX DOMAIN (MAP2K5-PHOX) WITH HUMAN MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3 (MAP3K3B-PHOX)
Descriptor:Dual specificity mitogen-activated protein kinase kinase 5, Mitogen-activated protein kinase kinase kinase 3
Authors:Filippakopoulos, P., Savitsky, P., Ugochukwu, E., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2006-11-30
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)
To be Published
2QG1
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CRYSTAL STRUCTURE OF THE 11TH PDZ DOMAIN OF MPDZ (MUPP1)
Descriptor:Multiple PDZ domain protein, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Salah, E., Phillips, C., Savitsky, P., Boisguerin, P., Oschkinat, H., Gileadi, C., Yang, X., Elkins, J.M., Ugochukwu, E., Bunkoczi, G., Uppenberg, J., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2007-06-28
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the 11th PDZ domain of MPDZ (MUPP1).
To be Published
2WM3
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CRYSTAL STRUCTURE OF NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1 IN COMPLEX WITH NIFLUMIC ACID
Descriptor:NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}NICOTINIC ACID, ...
Authors:Bhatia, C., Yue, W.W., Niesen, F., Pilka, E., Ugochukwu, E., Savitsky, P., Hozjan, V., Roos, A.K., Filippakopoulos, P., von Delft, F., Heightman, T., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-06-29
Release date:2009-08-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Nmra-Like Family Domain Containing Protein 1 in Complex with Niflumic Acid
To be Published
2WMD
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CRYSTAL STRUCTURE OF NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1 IN COMPLEX WITH NADP AND 2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID
Descriptor:NMRA-LIKE FAMILY DOMAIN CONTAINING PROTEIN 1, 2-(4-CHLORO-PHENYLAMINO)-NICOTINIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bhatia, C., Pilka, E., Niesen, F., Yue, W.W., Ugochukwu, E., Savitsky, P., Hozjan, V., Roos, A.K., Filippakopoulos, P., von Delft, F., Heightman, T., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-06-30
Release date:2009-07-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Nmra-Like Family Domain Containing Protein 1
To be Published
2XXZ
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CRYSTAL STRUCTURE OF THE HUMAN JMJD3 JUMONJI DOMAIN
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 6B, NICKEL (II) ION, SODIUM ION, ...
Authors:Che, K.H., Yue, W.W., Krojer, T., Muniz, J.R.C., Ng, S.S., Tumber, A., Daniel, M., Burgess-Brown, N., Savitsky, P., Ugochukwu, E., Filippakopoulos, P., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-11-12
Release date:2010-11-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of the Human Jmjd3 Jumonji Domain
To be Published
2Y7J
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STRUCTURE OF HUMAN PHOSPHORYLASE KINASE, GAMMA 2
Descriptor:PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
Authors:Muniz, J.R.C., Shrestha, A., Savitsky, P., Wang, J., Rellos, P., Fedorov, O., Burgess-Brown, N., Brenner, B., Berridge, G., Elkins, J.M., Krojer, T., Vollmar, M., Che, K.H., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S.
Deposit date:2011-01-31
Release date:2011-02-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Human Phosphorylase Kinase, Gamma 2
To be Published
3EMW
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CRYSTAL STRUCTURE OF HUMAN SPLA/RYANODINE RECEPTOR DOMAIN AND SOCS BOX CONTAINING 2 (SPSB2) IN COMPLEX WITH A 20-RESIDUE VASA PEPTIDE
Descriptor:SPRY domain-containing SOCS box protein 2, Peptide (VASA), 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Sharpe, T., Keates, T., Murray, J.W., Savitsky, P., Roos, A.K., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2008-09-25
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010
3F2O
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CRYSTAL STRUCTURE OF HUMAN SPLA/RYANODINE RECEPTOR DOMAIN AND SOCS BOX CONTAINING 1 (SPSB1) IN COMPLEX WITH A 20-RESIDUE VASA PEPTIDE
Descriptor:SPRY domain-containing SOCS box protein 1, 20-mer peptide from ATP-dependent RNA helicase vasa
Authors:Filippakopoulos, P., Sharpe, T., Keates, T., Murray, J.W., Savitsky, P., Roos, A., Pike, A.C.W., Von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2008-10-30
Release date:2008-12-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010