3B7O
Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site
Summary for 3B7O
Entry DOI | 10.2210/pdb3b7o/pdb |
Related | 2SHP |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, D-MALATE (3 entities in total) |
Functional Keywords | shp2, ptpn11, tyrosine phosphatase, structural genomics, structural genomics consortium, sgc, deafness, disease mutation, hydrolase, phosphorylation, protein phosphatase, sh2 domain |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q06124 |
Total number of polymer chains | 1 |
Total formula weight | 37013.81 |
Authors | Ugochukwu, E.,Barr, A.,Patel, A.,King, O.,Niesen, F.,Salah, E.,Savitsky, P.,Pilka, E.S.,Elkins, J.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.M.,von Delft, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2007-10-31, release date: 2007-11-13, Last modification date: 2023-08-30) |
Primary citation | Barr, A.J.,Ugochukwu, E.,Lee, W.H.,King, O.N.,Filippakopoulos, P.,Alfano, I.,Savitsky, P.,Burgess-Brown, N.A.,Muller, S.,Knapp, S. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell(Cambridge,Mass.), 136:352-363, 2009 Cited by PubMed: 19167335DOI: 10.1016/j.cell.2008.11.038 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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