3B7O
Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 11 | polymer | 316 | 36879.7 | 1 | UniProt (Q06124) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase 2C, PTP-2C, PTP-1D, SH-PTP3, SH-PTP2, SHP-2, Shp2 |
2 | A | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
3 | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A: 237 - 529 (UniProt: Q06124)
PDB | External Database | Details |
---|---|---|
Met 214 | - | expression tag |
His 215 | - | expression tag |
His 216 | - | expression tag |
His 217 | - | expression tag |
His 218 | - | expression tag |
His 219 | - | expression tag |
His 220 | - | expression tag |
Ser 221 | - | expression tag |
Ser 222 | - | expression tag |
Gly 223 | - | expression tag |
Val 224 | - | expression tag |
Asp 225 | - | expression tag |
Leu 226 | - | expression tag |
Gly 227 | - | expression tag |
Thr 228 | - | expression tag |
Glu 229 | - | expression tag |
Asn 230 | - | expression tag |
Leu 231 | - | expression tag |
Tyr 232 | - | expression tag |
Phe 233 | - | expression tag |
Gln 234 | - | expression tag |
Ser 235 | - | expression tag |
Met 236 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36879.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 134.1 | |
All* | Total formula weight | 37013.8 |