3B7O

Crystal structure of the human tyrosine phosphatase SHP2 (PTPN11) with an accessible active site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein phosphatase non-receptor type 11	polymer	316	36879.7	1	UniProt (Q06124) Pfam (PF00102)	Homo sapiens (human)	Protein-tyrosine phosphatase 2C, PTP-2C, PTP-1D, SH-PTP3, SH-PTP2, SHP-2, Shp2
2	B (A)	D-MALATE	non-polymer		134.1	1	Chemie (MLT)
3	C (A)	water	water		18.0	241	Chemie (HOH)

Sequence modifications

A: 237 - 529 (UniProt: Q06124)

PDB	External Database	Details
Met 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
Ser 221	-	expression tag
Ser 222	-	expression tag
Gly 223	-	expression tag
Val 224	-	expression tag
Asp 225	-	expression tag
Leu 226	-	expression tag
Gly 227	-	expression tag
Thr 228	-	expression tag
Glu 229	-	expression tag
Asn 230	-	expression tag
Leu 231	-	expression tag
Tyr 232	-	expression tag
Phe 233	-	expression tag
Gln 234	-	expression tag
Ser 235	-	expression tag
Met 236	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36879.7
Non-Polymers*	Number of molecules	1
	Total formula weight	134.1
All*	Total formula weight	37013.8

*Water molecules are not included.