3GVU

The crystal structure of human ABL2 in complex with GLEEVEC

Summary for 3GVU

• Entry DOI: 10.2210/pdb3gvu/pdb
• Related: 1FPU
• Descriptor: Tyrosine-protein kinase ABL2, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total)
• Functional Keywords: tyrosine kinase, abl, abelson murine leukemia viral oncogene, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton: P42684
• Total number of polymer chains: 1
• Total formula weight: 34530.56

Authors

Ugochukwu, E.,Salah, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Chaikuad, A.,Filippakopoulos, P.,Roos, A.,Pike, A.C.W.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-03-31, release date: 2009-04-21, Last modification date: 2023-11-01)

• Primary citation: Salah, E.,Ugochukwu, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Knapp, S.; The crystal structure of human ABL2 in complex with GLEEVEC; To be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)