3GVU
The crystal structure of human ABL2 in complex with GLEEVEC
Summary for 3GVU
Entry DOI | 10.2210/pdb3gvu/pdb |
Related | 1FPU |
Descriptor | Tyrosine-protein kinase ABL2, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE (3 entities in total) |
Functional Keywords | tyrosine kinase, abl, abelson murine leukemia viral oncogene, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton: P42684 |
Total number of polymer chains | 1 |
Total formula weight | 34530.56 |
Authors | Ugochukwu, E.,Salah, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Chaikuad, A.,Filippakopoulos, P.,Roos, A.,Pike, A.C.W.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-03-31, release date: 2009-04-21, Last modification date: 2023-11-01) |
Primary citation | Salah, E.,Ugochukwu, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Knapp, S. The crystal structure of human ABL2 in complex with GLEEVEC To be Published, |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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