3GVU

The crystal structure of human ABL2 in complex with GLEEVEC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase ABL2	polymer	292	33543.4	1	UniProt (P42684) Pfam (PF07714)	Homo sapiens (human)	Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine kinase ARG
2	B, C (A)	4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE	non-polymer		493.6	2	Chemie (STI)
3	D (A)	water	water		18.0	149	Chemie (HOH)

Sequence modifications

A: 279 - 546 (UniProt: P42684)

PDB	External Database	Details
Met 255	-	expression tag
Gly 256	-	expression tag
His 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
Ser 263	-	expression tag
Ser 264	-	expression tag
Gly 265	-	expression tag
Val 266	-	expression tag
Asp 267	-	expression tag
Leu 268	-	expression tag
Gly 269	-	expression tag
Thr 270	-	expression tag
Glu 271	-	expression tag
Asn 272	-	expression tag
Leu 273	-	expression tag
Tyr 274	-	expression tag
Phe 275	-	expression tag
Gln 276	-	expression tag
Ser 277	-	expression tag
Met 278	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33543.4
Non-Polymers*	Number of molecules	2
	Total formula weight	987.2
All*	Total formula weight	34530.6

*Water molecules are not included.