3HMI
The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Summary for 3HMI
Entry DOI | 10.2210/pdb3hmi/pdb |
Related | 3GVU |
Descriptor | Tyrosine-protein kinase ABL2, 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE (3 entities in total) |
Functional Keywords | tyrosine kinase, abl, abl2, abelson murine leukemia viral oncogene, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, phosphoprotein, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase, structural genomics, structural genomics consortium, sgc |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton: P42684 |
Total number of polymer chains | 1 |
Total formula weight | 33968.79 |
Authors | Ugochukwu, E.,Salah, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Chaikuad, A.,Allerston, C.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-05-29, release date: 2009-07-07, Last modification date: 2023-11-01) |
Primary citation | Ugochukwu, E.,Salah, E.,Barr, A.,Mahajan, P.,Shrestha, B.,Savitsky, P.,Chaikuad, A.,Allerston, C.,von Delft, F.,Knapp, S. The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE To be Published, |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
Download full validation report