2IZZ

Crystal structure of human pyrroline-5-carboxylate reductase

Summary for 2IZZ

DescriptorPYRROLINE-5-CARBOXYLATE REDUCTASE 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsamino-acid biosynthesis, nadp, oxidoreductase, proline biosynthesis
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationMitochondrion  P32322
Total number of polymer chains5
Total molecular weight173967.38
Authors
Primary citation
Pike, A.C.W.,Guo, K.,Kavanagh, K.,Pilka, E.S.,Berridge, G.,Colebrook, S.,Bray, J.,Salah, E.,Savitsky, P.,Papagrigoriou, E.,Turnbull, A.P.,von Delft, F.,Arrowsmith, C.,Edwards, A.,Weigelt, J.,Sundstrom, M.,Oppermann, U.
Crystal Structure of Human Pyrroline-5-Carboxylate Reductase
To be Published,
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeRSRZ outliers0.1965.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2izz
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Molmil generated image of 2izz
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Molmil generated image of 2izz
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More Biological unit images

Molmil generated image of 2izz
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Molmil generated image of 2izz
rotated about x axis by 90°
Molmil generated image of 2izz
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2izz.pdb1.gz [432.88 KB])