2YGW

Crystal structure of human MCD

Summary for 2YGW

• Entry DOI: 10.2210/pdb2ygw/pdb
• Descriptor: MALONYL-COA DECARBOXYLASE, MITOCHONDRIAL, UNKNOWN ATOM OR ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: lyase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm : O95822
• Total number of polymer chains: 2
• Total formula weight: 102921.63

Authors

Vollmar, M.,Puranik, S.,Krojer, T.,Savitsky, P.,Allerston, C.,Yue, W.W.,Chaikuad, A.,von Delft, F.,Gileadi, O.,Kavanagh, K.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,Oppermann, U. (deposition date: 2011-04-21, release date: 2012-02-15, Last modification date: 2018-01-24)

• Primary citation: Froese, D.S.,Forouhar, F.,Tran, T.H.,Vollmar, M.,Kim, Y.S.,Lew, S.,Neely, H.,Seetharaman, J.,Shen, Y.,Xiao, R.,Acton, T.B.,Everett, J.K.,Cannone, G.,Puranik, S.,Savitsky, P.,Krojer, T.,Pilka, E.S.,Kiyani, W.,Lee, W.H.,Marsden, B.D.,von Delft, F.,Allerston, C.K.,Spagnolo, L.,Gileadi, O.,Montelione, G.T.,Oppermann, U.,Yue, W.W.,Tong, L.; Crystal Structures of Malonyl-Coenzyme a Decarboxylase Provide Insights Into its Catalytic Mechanism and Disease-Causing Mutations.; Structure, 21:1182-, 2013; PubMed: 23791943; DOI: 10.1016/J.STR.2013.05.001

Experimental method

X-RAY DIFFRACTION (2.8 Å)