3FME

Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D)

Summary for 3FME

• Entry DOI: 10.2210/pdb3fme/pdb
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 6, STAUROSPORINE (3 entities in total)
• Functional Keywords: kinase, active mutant, structural genomics consortium, scg, sgc, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P52564
• Total number of polymer chains: 1
• Total formula weight: 33216.42

Authors

Filippakopoulos, P.,Barr, A.,Pike, A.C.W.,Berridge, G.,Elkins, J.,Fedorov, O.,Keates, T.,Savitsky, P.,Soundararajan, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-12-21, release date: 2009-01-06, Last modification date: 2023-09-06)

• Primary citation: Filippakopoulos, P.,Barr, A.,Pike, A.C.W.,Berridge, G.,Elkins, J.,Fedorov, O.,Keates, T.,Savitsky, P.,Soundararajan, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.; Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D); To be Published,

Experimental method

X-RAY DIFFRACTION (2.26 Å)