3FME
Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 6 | polymer | 290 | 32749.9 | 1 | UniProt (P52564) Pfam (PF00069) | Homo sapiens (Human) | MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, SAPKK3 |
| 2 | B (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (5279) PubChem (71203703) PubChem (42610657) PubChem (44259) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (451705) PubChem (73953205) PubChem (86306248) PubChem (358479) PubChem (5280487) PubChem (5459111) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (6419748) PubChem (9804568) PubChem (122130844) PubChem (12046017) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 3 | C (A) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 47 - 334 (UniProt: P52564)
| PDB | External Database | Details |
|---|---|---|
| Ser 45 | - | expression tag |
| Met 46 | - | expression tag |
| Asp 207 | Ser 207 | engineered mutation |
| Asp 211 | Thr 211 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32749.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 466.5 | |
| All* | Total formula weight | 33216.4 |
