3FME
Crystal Structure of Human Mitogen-Activated Protein Kinase Kinase 6 (MEK6) Activated Mutant (S207D, T211D)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 6 | polymer | 290 | 32749.9 | 1 | UniProt (P52564) Pfam (PF00069) | Homo sapiens (Human) | MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, SAPKK3 |
| 2 | B (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) | |||
| 3 | C (A) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 47 - 334 (UniProt: P52564)
| PDB | External Database | Details |
|---|---|---|
| Ser 45 | - | expression tag |
| Met 46 | - | expression tag |
| Asp 207 | Ser 207 | engineered mutation |
| Asp 211 | Thr 211 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32749.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 466.5 | |
| All* | Total formula weight | 33216.4 |
