3OP5

Human vaccinia-related kinase 1

Summary for 3OP5

• Entry DOI: 10.2210/pdb3op5/pdb
• Descriptor: Serine/threonine-protein kinase VRK1, [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}amino)phenyl]acetonitrile, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: adenosine triphosphate, amino acid sequence, binding sites, catalytic domain, models, molecular, molecular sequence data, phosphotransferases, protein conformation, protein folding, surface entropy reduction, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 166372.52

Authors

Allerston, C.K.,Uttarkar, S.,Savitsky, P.,Elkins, J.M.,Filippakopoulos, P.,Krojer, T.,Rellos, P.,Fedorov, O.,Eswaran, J.,Brenner, B.,Keates, T.,Das, S.,King, O.,Chalk, R.,Berridge, G.,von Delft, F.,Gileadi, O.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-08-31, release date: 2010-09-22, Last modification date: 2023-09-06)

• Primary citation: Counago, R.M.,Allerston, C.K.,Savitsky, P.,Azevedo, H.,Godoi, P.H.,Wells, C.I.,Mascarello, A.,de Souza Gama, F.H.,Massirer, K.B.,Zuercher, W.J.,Guimaraes, C.R.W.,Gileadi, O.; Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.; Sci Rep, 7:7501-7501, 2017; PubMed: 28790404; DOI: 10.1038/s41598-017-07755-y

Experimental method

X-RAY DIFFRACTION (2.4 Å)