3OP5

Human vaccinia-related kinase 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004676	molecular_function	3-phosphoinositide-dependent protein kinase activity
A	0004677	molecular_function	DNA-dependent protein kinase activity
A	0004679	molecular_function	AMP-activated protein kinase activity
A	0004694	molecular_function	eukaryotic translation initiation factor 2alpha kinase activity
A	0004711	molecular_function	ribosomal protein S6 kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005795	cellular_component	Golgi stack
A	0005829	cellular_component	cytosol
A	0006338	biological_process	chromatin remodeling
A	0006468	biological_process	protein phosphorylation
A	0006974	biological_process	DNA damage response
A	0007077	biological_process	mitotic nuclear membrane disassembly
A	0007165	biological_process	signal transduction
A	0015030	cellular_component	Cajal body
A	0016301	molecular_function	kinase activity
A	0019901	molecular_function	protein kinase binding
A	0030576	biological_process	Cajal body organization
A	0031175	biological_process	neuron projection development
A	0031492	molecular_function	nucleosomal DNA binding
A	0035175	molecular_function	histone H3S10 kinase activity
A	0035402	molecular_function	histone H3T11 kinase activity
A	0035403	molecular_function	histone H3T6 kinase activity
A	0035979	molecular_function	histone H2AXS139 kinase activity
A	0042393	molecular_function	histone binding
A	0044022	molecular_function	histone H3S28 kinase activity
A	0044023	molecular_function	histone H4S1 kinase activity
A	0044024	molecular_function	histone H2AS1 kinase activity
A	0044025	molecular_function	histone H2BS14 kinase activity
A	0046777	biological_process	protein autophosphorylation
A	0051301	biological_process	cell division
A	0072354	molecular_function	histone H3T3 kinase activity
A	0072371	molecular_function	histone H2AS121 kinase activity
A	0072518	molecular_function	Rho-dependent protein serine/threonine kinase activity
A	0090166	biological_process	Golgi disassembly
A	0106310	molecular_function	protein serine kinase activity
A	0120187	biological_process	positive regulation of protein localization to chromatin
A	0140823	molecular_function	histone H2BS36 kinase activity
A	0140855	molecular_function	histone H3S57 kinase activity
A	0140857	molecular_function	histone H3T45 kinase activity
A	0141003	molecular_function	histone H2AX kinase activity
A	1990244	molecular_function	histone H2AT120 kinase activity
A	2001222	biological_process	regulation of neuron migration
B	0000785	cellular_component	chromatin
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004676	molecular_function	3-phosphoinositide-dependent protein kinase activity
B	0004677	molecular_function	DNA-dependent protein kinase activity
B	0004679	molecular_function	AMP-activated protein kinase activity
B	0004694	molecular_function	eukaryotic translation initiation factor 2alpha kinase activity
B	0004711	molecular_function	ribosomal protein S6 kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005795	cellular_component	Golgi stack
B	0005829	cellular_component	cytosol
B	0006338	biological_process	chromatin remodeling
B	0006468	biological_process	protein phosphorylation
B	0006974	biological_process	DNA damage response
B	0007077	biological_process	mitotic nuclear membrane disassembly
B	0007165	biological_process	signal transduction
B	0015030	cellular_component	Cajal body
B	0016301	molecular_function	kinase activity
B	0019901	molecular_function	protein kinase binding
B	0030576	biological_process	Cajal body organization
B	0031175	biological_process	neuron projection development
B	0031492	molecular_function	nucleosomal DNA binding
B	0035175	molecular_function	histone H3S10 kinase activity
B	0035402	molecular_function	histone H3T11 kinase activity
B	0035403	molecular_function	histone H3T6 kinase activity
B	0035979	molecular_function	histone H2AXS139 kinase activity
B	0042393	molecular_function	histone binding
B	0044022	molecular_function	histone H3S28 kinase activity
B	0044023	molecular_function	histone H4S1 kinase activity
B	0044024	molecular_function	histone H2AS1 kinase activity
B	0044025	molecular_function	histone H2BS14 kinase activity
B	0046777	biological_process	protein autophosphorylation
B	0051301	biological_process	cell division
B	0072354	molecular_function	histone H3T3 kinase activity
B	0072371	molecular_function	histone H2AS121 kinase activity
B	0072518	molecular_function	Rho-dependent protein serine/threonine kinase activity
B	0090166	biological_process	Golgi disassembly
B	0106310	molecular_function	protein serine kinase activity
B	0120187	biological_process	positive regulation of protein localization to chromatin
B	0140823	molecular_function	histone H2BS36 kinase activity
B	0140855	molecular_function	histone H3S57 kinase activity
B	0140857	molecular_function	histone H3T45 kinase activity
B	0141003	molecular_function	histone H2AX kinase activity
B	1990244	molecular_function	histone H2AT120 kinase activity
B	2001222	biological_process	regulation of neuron migration
C	0000785	cellular_component	chromatin
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004676	molecular_function	3-phosphoinositide-dependent protein kinase activity
C	0004677	molecular_function	DNA-dependent protein kinase activity
C	0004679	molecular_function	AMP-activated protein kinase activity
C	0004694	molecular_function	eukaryotic translation initiation factor 2alpha kinase activity
C	0004711	molecular_function	ribosomal protein S6 kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005795	cellular_component	Golgi stack
C	0005829	cellular_component	cytosol
C	0006338	biological_process	chromatin remodeling
C	0006468	biological_process	protein phosphorylation
C	0006974	biological_process	DNA damage response
C	0007077	biological_process	mitotic nuclear membrane disassembly
C	0007165	biological_process	signal transduction
C	0015030	cellular_component	Cajal body
C	0016301	molecular_function	kinase activity
C	0019901	molecular_function	protein kinase binding
C	0030576	biological_process	Cajal body organization
C	0031175	biological_process	neuron projection development
C	0031492	molecular_function	nucleosomal DNA binding
C	0035175	molecular_function	histone H3S10 kinase activity
C	0035402	molecular_function	histone H3T11 kinase activity
C	0035403	molecular_function	histone H3T6 kinase activity
C	0035979	molecular_function	histone H2AXS139 kinase activity
C	0042393	molecular_function	histone binding
C	0044022	molecular_function	histone H3S28 kinase activity
C	0044023	molecular_function	histone H4S1 kinase activity
C	0044024	molecular_function	histone H2AS1 kinase activity
C	0044025	molecular_function	histone H2BS14 kinase activity
C	0046777	biological_process	protein autophosphorylation
C	0051301	biological_process	cell division
C	0072354	molecular_function	histone H3T3 kinase activity
C	0072371	molecular_function	histone H2AS121 kinase activity
C	0072518	molecular_function	Rho-dependent protein serine/threonine kinase activity
C	0090166	biological_process	Golgi disassembly
C	0106310	molecular_function	protein serine kinase activity
C	0120187	biological_process	positive regulation of protein localization to chromatin
C	0140823	molecular_function	histone H2BS36 kinase activity
C	0140855	molecular_function	histone H3S57 kinase activity
C	0140857	molecular_function	histone H3T45 kinase activity
C	0141003	molecular_function	histone H2AX kinase activity
C	1990244	molecular_function	histone H2AT120 kinase activity
C	2001222	biological_process	regulation of neuron migration
D	0000785	cellular_component	chromatin
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004676	molecular_function	3-phosphoinositide-dependent protein kinase activity
D	0004677	molecular_function	DNA-dependent protein kinase activity
D	0004679	molecular_function	AMP-activated protein kinase activity
D	0004694	molecular_function	eukaryotic translation initiation factor 2alpha kinase activity
D	0004711	molecular_function	ribosomal protein S6 kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005795	cellular_component	Golgi stack
D	0005829	cellular_component	cytosol
D	0006338	biological_process	chromatin remodeling
D	0006468	biological_process	protein phosphorylation
D	0006974	biological_process	DNA damage response
D	0007077	biological_process	mitotic nuclear membrane disassembly
D	0007165	biological_process	signal transduction
D	0015030	cellular_component	Cajal body
D	0016301	molecular_function	kinase activity
D	0019901	molecular_function	protein kinase binding
D	0030576	biological_process	Cajal body organization
D	0031175	biological_process	neuron projection development
D	0031492	molecular_function	nucleosomal DNA binding
D	0035175	molecular_function	histone H3S10 kinase activity
D	0035402	molecular_function	histone H3T11 kinase activity
D	0035403	molecular_function	histone H3T6 kinase activity
D	0035979	molecular_function	histone H2AXS139 kinase activity
D	0042393	molecular_function	histone binding
D	0044022	molecular_function	histone H3S28 kinase activity
D	0044023	molecular_function	histone H4S1 kinase activity
D	0044024	molecular_function	histone H2AS1 kinase activity
D	0044025	molecular_function	histone H2BS14 kinase activity
D	0046777	biological_process	protein autophosphorylation
D	0051301	biological_process	cell division
D	0072354	molecular_function	histone H3T3 kinase activity
D	0072371	molecular_function	histone H2AS121 kinase activity
D	0072518	molecular_function	Rho-dependent protein serine/threonine kinase activity
D	0090166	biological_process	Golgi disassembly
D	0106310	molecular_function	protein serine kinase activity
D	0120187	biological_process	positive regulation of protein localization to chromatin
D	0140823	molecular_function	histone H2BS36 kinase activity
D	0140855	molecular_function	histone H3S57 kinase activity
D	0140857	molecular_function	histone H3T45 kinase activity
D	0141003	molecular_function	histone H2AX kinase activity
D	1990244	molecular_function	histone H2AT120 kinase activity
D	2001222	biological_process	regulation of neuron migration

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE REB A 365

Chain	Residue
A	ILE43
A	ARG133
A	PHE134
A	HOH368
A	HOH487
A	GLY44
A	GLN45
A	PHE48
A	ILE51
A	VAL69
A	TYR87
A	MET131
A	ASP132

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 366

Chain	Residue
A	GLN139
A	ALA180
A	PHE227
A	CYS250
A	GLN253
A	TRP254
A	HOH412

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 367

Chain	Residue
A	LYS85
A	ARG89
A	HOH427
A	HOH456
C	HOH532

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE REB B 365

Chain	Residue
B	GLY44
B	GLN45
B	PHE48
B	ILE51
B	VAL69
B	LYS71
B	TYR87
B	MET131
B	ASP132
B	ARG133
B	PHE134
B	HOH369

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 366

Chain	Residue
B	ARG89
B	HOH370
B	HOH447
D	HOH411

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 367

Chain	Residue
B	SER229
B	ILE230
B	ASP231
B	ARG241
B	GLU245
B	ARG279
B	HOH395

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE REB C 365

Chain	Residue
C	ILE43
C	GLY44
C	ILE51
C	VAL69
C	MET131
C	ASP132
C	ARG133
C	PHE134
C	HOH369
C	HOH449

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 366

Chain	Residue
C	SER229
C	ILE230
C	ASP231
C	GLU245
C	ARG279
C	HOH399

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 367

Chain	Residue
A	LYS85
A	GLN88
A	ARG89
A	LYS92
C	ASP310
C	GLU313
C	EDO368

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 368

Chain	Residue
C	ASP310
C	THR312
C	GLU313
C	EDO367

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE REB D 365

Chain	Residue
D	ILE43
D	ILE51
D	VAL69
D	MET131
D	ASP132
D	ARG133
D	PHE134
D	HOH366

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGQGGFGCIYlAdmnssesvgsdap.....CVVK

Chain	Residue	Details
A	ILE43-LYS71

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. YvHgDIKasNLLL

Chain	Residue	Details
A	TYR173-LEU185

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP177
B	ASP177
C	ASP177
D	ASP177

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE43
A	LYS71
B	ILE43
B	LYS71
C	ILE43
C	LYS71
D	ILE43
D	LYS71

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:19103756, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER342
B	SER342
C	SER342
D	SER342

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:11883897

Chain	Residue	Details
A	THR355
B	THR355
C	THR355
D	THR355

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS71
B	LYS71
C	LYS71
D	LYS71

---