1ZX1 | | HUMAN QUINONE OXIDOREDUCTASE 2 (NQO2) IN COMPLEX WITH THE CYTOSTATIC PRODRUG CB1954 | | Descriptor: | NRH dehydrogenase [quinone] 2, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Jansson, A., Wu, X., Kavanagh, K., Kerr, D., Knox, R., Walton, R., Gunther, U., Ludwig, C., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-06-06 | | Release date: | 2005-06-14 | | Last modified: | 2018-12-12 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Human quinone oxidoreductase 2 (NQO2) in complex with the cytostatic prodrug CB1954
To be Published
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4UF0 | | CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY IN COMPLEX WITH EPITHERAPUETIC COMPOUND 2-(((2-((2-(DIMETHYLAMINO)ETHYL) (ETHYL)AMINO)-2-OXOETHYL)AMINO)METHYL)ISONICOTINIC ACID. | | Descriptor: | HISTONE DEMETHYLASE UTY, FE (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ... | | Authors: | Srikannathasan, V., Johansson, C., Gileadi, C., Tobias, K., Kopec, J., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U. | | Deposit date: | 2014-12-22 | | Release date: | 2015-01-14 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5A1F | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PLU1 IN COMPLEX WITH N-OXALYLGLYCINE. | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, N-OXALYLGLYCINE, ... | | Authors: | Srikannathasan, V., Johansson, C., Strain-Damerell, C., Gileadi, C., Szykowska, A., Kupinska, K., Kopec, J., Krojer, T., Steuber, H., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U. | | Deposit date: | 2015-04-29 | | Release date: | 2015-05-06 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5A3P | | CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLU1 (JARID1B). | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ... | | Authors: | Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Tallant, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U. | | Deposit date: | 2015-06-02 | | Release date: | 2015-06-10 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.008 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5A3T | | CRYSTAL STRUCTURE OF HUMAN PLU-1 (JARID1B) IN COMPLEX WITH KDM5-C49 (2-(((2-((2-(DIMETHYLAMINO)ETHYL)(ETHYL)AMINO)-2-OXOETHYL)AMINO)METHYL) ISONICOTINIC ACID). | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., Strain-Damerell, C., Kupinska, K., BurgessBrown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U. | | Deposit date: | 2015-06-02 | | Release date: | 2015-06-17 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5A3W | | CRYSTAL STRUCTURE OF HUMAN PLU-1 (JARID1B) IN COMPLEX WITH PYRIDINE-2, 6-DICARBOXYLIC ACID (PDCA) | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, SODIUM ION, ... | | Authors: | Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., Strain-Damerell, C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U. | | Deposit date: | 2015-06-03 | | Release date: | 2015-06-17 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5FPU | | CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH GSKJ1 | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ... | | Authors: | Srikannathasan, V., Nowak, R., Johansson, C., Gileadi, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U. | | Deposit date: | 2015-12-03 | | Release date: | 2016-01-13 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5FPV | | CRYSTAL STRUCTURE OF HUMAN JMJD2A IN COMPLEX WITH COMPOUND KDOAM20A | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 4A, MANGANESE (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ... | | Authors: | Srikannathasan, V., Gileadi, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U. | | Deposit date: | 2015-12-03 | | Release date: | 2016-01-13 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5FUN | | CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH GSK467 | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 2-[(1-benzyl-1H-pyrazol-4-yl)oxy]pyrido[3,4-d]pyrimidin-4(3H)-one, ... | | Authors: | Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Brennan, P., Oppermann, U. | | Deposit date: | 2016-01-28 | | Release date: | 2016-04-13 | | Last modified: | 2016-06-29 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5FUP | | CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH 2-OXOGLUTARATE. | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ... | | Authors: | Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U. | | Deposit date: | 2016-01-28 | | Release date: | 2016-03-23 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5FV3 | | CRYSTAL STRUCTURE OF HUMAN JARID1B CONSTRUCT C2 IN COMPLEX WITH N- OXALYLGLYCINE. | | Descriptor: | LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ... | | Authors: | Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U. | | Deposit date: | 2016-02-02 | | Release date: | 2016-02-17 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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5FWJ | | CRYSTAL STRUCTURE OF HUMAN JARID1C IN COMPLEX WITH KDM5-C49 | | Descriptor: | HISTONE DEMETHYLASE JARID1C, MAGNESIUM ION, ZINC ION, ... | | Authors: | Srikannathasan, V., Szykowska, A., Strain-Damerell, C., Kopec, J., Nowak, R., Gileadi, C., Johansson, C., Kupinska, K., Burgess-Brown, N.A., Shrestha, L., Dong, W., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Huber, K., Oppermann, U. | | Deposit date: | 2016-02-17 | | Release date: | 2016-04-13 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
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1T2A | | CRYSTAL STRUCTURE OF HUMAN GDP-D-MANNOSE 4,6-DEHYDRATASE | | Descriptor: | GDP-mannose 4,6 dehydratase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Walker, J.R., Vedadi, M., Sharma, S., Houston, S., Wasney, G., Loppnau, P., Sundstrom, M., Arrowsmith, C., Edwards, A., Oppermann, U. | | Deposit date: | 2004-04-20 | | Release date: | 2004-05-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Crystal Structure and Biophysical Characterization of Human GDP-D-mannose 4,6-dehydratase
To be Published
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1XG5 | | STRUCTURE OF HUMAN PUTATIVE DEHYDROGENASE MGC4172 IN COMPLEX WITH NADP | | Descriptor: | ARPG836, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETIC ACID | | Authors: | Kavanagh, K., Ng, S., Sharma, S., Vedadi, M., von Delft, F., Walker, J.R., dhe Paganon, S., Bray, J., Oppermann, U., Edwards, A., Arrowsmith, C., Sundstrom, M., Structural Genomics Consortium (SGC) | | Deposit date: | 2004-09-16 | | Release date: | 2004-10-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Structural Genomics Consortium: Structure of the putative human dehydrogenase MGC4172
To be Published
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1XSE | | CRYSTAL STRUCTURE OF GUINEA PIG 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | | Descriptor: | 11beta-hydroxysteroid dehydrogenase type 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Ogg, D., Elleby, B., Norstrom, C., Stefansson, K., Abrahmsen, L., Oppermann, U., Svensson, S. | | Deposit date: | 2004-10-19 | | Release date: | 2004-11-16 | | Last modified: | 2018-08-08 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions
J.Biol.Chem., 280, 2005
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1YB1 | | CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE XI | | Descriptor: | 17-beta-hydroxysteroid dehydrogenase type XI, CHLORIDE ION, SULFATE ION, ... | | Authors: | Lukacik, P., Bunkoczi, G., Kavanagh, K., Ng, S., von Delft, F., Bray, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2004-12-18 | | Release date: | 2004-12-28 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI.
To be Published
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1YB5 | | CRYSTAL STRUCTURE OF HUMAN ZETA-CRYSTALLIN WITH BOUND NADP | | Descriptor: | Quinone oxidoreductase, ACETATE ION, CHLORIDE ION, ... | | Authors: | Debreczeni, J., Berridge, G., Kavanagh, K., Colbrook, S., Bray, J., Williams, L., Oppermann, U., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., von Delft, F., Structural Genomics Consortium (SGC) | | Deposit date: | 2004-12-20 | | Release date: | 2004-12-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structure of human Zeta-Crystallin at 1.85A
To be Published
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1YDE | | CRYSTAL STRUCTURE OF HUMAN RETINAL SHORT-CHAIN DEHYDROGENASE/REDUCTASE 3 | | Descriptor: | Retinal dehydrogenase/reductase 3 | | Authors: | Lukacik, P., Bunkozci, G., Kavanagh, K., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2004-12-23 | | Release date: | 2005-01-18 | | Last modified: | 2012-03-14 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.
Biochem.J., 402, 2007
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1YQ7 | | HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH RISEDRONATE | | Descriptor: | Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Kavanagh, K.L., Guo, K., Von delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-02-01 | | Release date: | 2005-02-22 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Human farnesyl diphosphate complexed with clinical inhibitor risedronate
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1YV5 | | HUMAN FARNESYL DIPHOSPHATE SYNTHASE COMPLEXED WITH MG AND RISEDRONATE | | Descriptor: | Farnesyl pyrophosphate synthetase, MAGNESIUM ION, PHOSPHATE ION, ... | | Authors: | Kavanagh, K.L., Guo, K., Von Delft, F., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-02-15 | | Release date: | 2005-03-01 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
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1YXM | | CRYSTAL STRUCTURE OF PEROXISOMAL TRANS 2-ENOYL COA REDUCTASE | | Descriptor: | peroxisomal trans 2-enoyl CoA reductase, SULFATE ION, PHOSPHATE ION, ... | | Authors: | Jansson, A., Ng, S., Arrowsmith, C., Sharma, S., Edwards, A.M., Von Delft, F., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-02-22 | | Release date: | 2005-03-15 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of perixomal trans 2-enoyl CoA reductase (PECRA)
To be Published
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1Z6Z | | CRYSTAL STRUCTURE OF HUMAN SEPIAPTERIN REDUCTASE IN COMPLEX WITH NADP+ | | Descriptor: | Sepiapterin reductase, SULFATE ION, CHLORIDE ION, ... | | Authors: | Ugochukwu, E., Kavanagh, K., Ng, S., Arrowsmith, C., Edwards, A., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-03-23 | | Release date: | 2005-04-05 | | Last modified: | 2018-04-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of Human Sepiapterin Reductase
To be Published
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1ZBQ | | CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 4 IN COMPLEX WITH NAD | | Descriptor: | 17-beta-hydroxysteroid dehydrogenase 4, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Lukacik, P., Shafqat, N., Kavanagh, K., Bray, J., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-04-08 | | Release date: | 2005-04-26 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
To be Published
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1ZSV | | CRYSTAL STRUCTURE OF HUMAN NADP-DEPENDENT LEUKOTRIENE B4 12-HYDROXYDEHYDROGENASE | | Descriptor: | NADP-dependent leukotriene B4 12-hydroxydehydrogenase, CHLORIDE ION | | Authors: | Turnbull, A.P., Johansson, C., Savitsky, P., Guo, K., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-05-25 | | Release date: | 2005-06-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase
To be Published
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1ZSX | | CRYSTAL STRUCTURE OF HUMAN POTASSIUM CHANNEL KV BETA-SUBUNIT (KCNAB2) | | Descriptor: | Voltage-gated potassium channel beta-2 subunit, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Wennerstrand, P., Johannsson, I., Ugochukwu, E., Kavanagh, K., Edwards, A., Arrowsmith, C., Williams, L., Sundstrom, M., Guo, K., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2005-05-25 | | Release date: | 2005-06-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure Of Human Potassium Channel Kv Beta-subunit (KCNAB2)
To be Published
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