4OGU

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

Summary for 4OGU

• Entry DOI: 10.2210/pdb4ogu/pdb
• Related: 1ZW5 4N9U 4NG6 4NUA
• Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: all alpha-helical, prenyltransferase, transferase, isoprene biosynthesis, lipid biosynthesis, steroid biosynthesis, isoprenoid pathway, cholesterol synthesis
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43652.99

Authors

Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. (deposition date: 2014-01-16, release date: 2015-01-21, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E.; The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)