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4OGU

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

Functional Information from GO Data
ChainGOidnamespacecontents
A0004659molecular_functionprenyltransferase activity
A0008299biological_processisoprenoid biosynthetic process
A0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 401
ChainResidue
AASP103
AASP107
AMG403
A210405
AHOH504
AHOH593
AHOH594

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 402
ChainResidue
AHOH590
AHOH591
AHOH592
AASP243
A210405

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 403
ChainResidue
AASP103
AASP107
AMG401
A210405
AHOH586
AHOH587
AHOH588

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE IPE A 404
ChainResidue
AGLY56
ALYS57
AARG60
AGLN96
AARG113
ATHR201
ATYR204
AGLN240
AASP243
A210405
AHOH505
AHOH507
AHOH596
AHOH597
AHOH600

site_idAC5
Number of Residues23
DetailsBINDING SITE FOR RESIDUE 210 A 405
ChainResidue
AASP103
AASP107
AARG112
ALYS200
ATHR201
AGLN240
AASP243
ALYS257
AMG401
AMG402
AMG403
AIPE404
AHOH504
AHOH546
AHOH586
AHOH588
AHOH589
AHOH590
AHOH591
AHOH592
AHOH593
AHOH594
AHOH601

Functional Information from PROSITE/UniProt
site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVaDDim..DssltRRG
ChainResidueDetails
ALEU100-GLY114

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16684881, ECO:0007744|PDB:1ZW5
ChainResidueDetails
ALYS57
AARG60
AGLN96
AASP103
AASP107
AARG113

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING:
ChainResidueDetails
AARG112
ALYS200
ATHR201
AGLN240
ALYS257

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALYS266

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Important for determining product chain length => ECO:0000250
ChainResidueDetails
APHE98
APHE99

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS57

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS287

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PDB entries from 2024-07-24

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