6GPJ

Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4F-Man

Summary for 6GPJ

• Entry DOI: 10.2210/pdb6gpj/pdb
• Descriptor: GDP-mannose 4,6 dehydratase, CITRIC ACID, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{S},6~{R})-5-fluoranyl-6-(hydroxymethyl)-3,4-bis(oxidanyl)oxan-2-yl] hydrogen phosphate, ... (6 entities in total)
• Functional Keywords: gdp-mannose 4, 6 dehydratase, fucosylation, structural genomics, structural genomics consortium, sgc, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 166137.19

Authors

Pfeiffer, M.,Krojer, T.,Johansson, C.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.,Nidetzky, B.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2018-06-06, release date: 2018-07-18, Last modification date: 2024-01-17)

• Primary citation: Pfeiffer, M.,Johansson, C.,Krojer, T.,Kavanagh, K.L.,Oppermann, U.,Nidetzky, B.; A Parsimonious Mechanism of Sugar Dehydration by Human GDP-Mannose-4,6-dehydratase.; Acs Catalysis, 9:2962-2968, 2019; PubMed: 30984471; DOI: 10.1021/acscatal.9b00064

Experimental method

X-RAY DIFFRACTION (1.94 Å)