6GPJ
Crystal structure of human GDP-D-mannose 4,6-dehydratase in complex with GDP-4F-Man
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, C, B) | GDP-mannose 4,6 dehydratase | polymer | 352 | 40056.5 | 4 | UniProt (O60547) Pfam (PF16363) | Homo sapiens (Human) | GDP-D-mannose dehydratase,GMD |
| 2 | E, N (A, B) | CITRIC ACID | non-polymer | 192.1 | 2 | Chemie (CIT) | |||
| 3 | F, I, K, O (A, D, C, B) | [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{S},6~{R})-5-fluoranyl-6-(hydroxymethyl)-3,4-bis(oxidanyl)oxan-2-yl] hydrogen phosphate | non-polymer | 607.3 | 4 | Chemie (G4F) | |||
| 4 | G, J, L, P (A, D, C, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 5 | H, M (D, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | Q, R, S, T (A, D, C, B) | water | water | 18.0 | 736 | Chemie (HOH) |
Sequence modifications
A, D, C, B: 23 - 372 (UniProt: O60547)
| PDB | External Database | Details |
|---|---|---|
| Ser 21 | - | expression tag |
| Met 22 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 160225.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 5911.3 | |
| All* | Total formula weight | 166137.2 |
