4NG6

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

Summary for 4NG6

• Entry DOI: 10.2210/pdb4ng6/pdb
• Related: 1YQ7 4KFA 4KQ5 4KQS
• Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: alpha-helical prenyltransferase, isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, isoprenoid pathway, cholesterol synthesis, bisphosphonates
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43731.08

Authors

Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E. (deposition date: 2013-11-01, release date: 2014-11-19, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E.; The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates; TO BE PUBLISHED,

Experimental method

X-RAY DIFFRACTION (2.35 Å)