4NG6
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Summary for 4NG6
Entry DOI | 10.2210/pdb4ng6/pdb |
Related | 1YQ7 4KFA 4KQ5 4KQS |
Descriptor | Farnesyl pyrophosphate synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | alpha-helical prenyltransferase, isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, isoprenoid pathway, cholesterol synthesis, bisphosphonates |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43731.08 |
Authors | Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E. (deposition date: 2013-11-01, release date: 2014-11-19, Last modification date: 2023-09-20) |
Primary citation | Tsoumpra, M.K.,Muniz, J.R.C.,Barnett, B.L.,Pilka, E.,Kwaasi, A.A.,Kavanagh, K.L.,Evdokimov, A.,Walter, R.L.,Ebetino, F.H.,Oppermann, U.,Russell, R.G.G.,Dunford, J.E. The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates TO BE PUBLISHED, |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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