4NUA
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
Summary for 4NUA
Entry DOI | 10.2210/pdb4nua/pdb |
Related | 1YQ7 4N9U 4NG6 4NKE 4NKF |
Descriptor | Farnesyl pyrophosphate synthase, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | cholesterol synthesis, alpha-helical prenyltransferase fold, transferase, isoprene synthesis, lipid synthesis, steroid biosynthesis, isoprenoid pathway, dimethylallyl pyrophosphate, isopentenyl pyrophosphate |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 43894.26 |
Authors | Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. (deposition date: 2013-12-03, release date: 2014-11-19, Last modification date: 2023-09-20) |
Primary citation | Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published, |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
Download full validation report