4NKE

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

Summary for 4NKE

• Entry DOI: 10.2210/pdb4nke/pdb
• Related: 1YQ7 1ZW5 4N9U 4NG6 4NKF 4NUA
• Descriptor: Farnesyl pyrophosphate synthase, MAGNESIUM ION, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, ... (6 entities in total)
• Functional Keywords: alpha-helical prenyltransferase, isoprene biosynthesis, lipid synthesis, steroid biosynthesis, transferase, isoprenoid pathway, cholesterol synthesis, bisphosphonates
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14324
• Total number of polymer chains: 1
• Total formula weight: 43825.17

Authors

Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E. (deposition date: 2013-11-12, release date: 2014-11-19, Last modification date: 2023-09-20)

• Primary citation: Tsoumpra, M.K.,Barnett, B.L.,Muniz, J.R.C.,Walter, R.L.,Ebetino, F.H.,von Delft, F.,Russell, R.G.G.,Oppermann, U.,Dunford, J.E.; The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates; To be Published,

Experimental method

X-RAY DIFFRACTION (1.46 Å)