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3MWI
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THE COMPLEX CRYSTAL STRUCTURE OF UROKIANSE AND 5-NITRO-1H-INDOLE-2-AMIDINE
Descriptor:Urokinase-type plasminogen activator, 5-nitro-1H-indole-2-carboximidamide, SULFATE ION
Authors:Jiang, L.G., Yu, H.Y., Yuan, C., Huang, Z.X., Huang, M.D.
Deposit date:2010-05-06
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The complex crystal Structure of Urokianse and 5-nitro-1H-indole-2-amidine
To be Published
3OX7
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THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH027 AT PH4.6
Descriptor:Urokinase-type plasminogen activator, MH027, SULFATE ION, ...
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-21
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY5
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THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH027 AT PH7.4
Descriptor:Urokinase-type plasminogen activator, MH027, SULFATE ION
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY6
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THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH036 AT PH4.6
Descriptor:Urokinase-type plasminogen activator, MH036
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
5YC6
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THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH 4-BROMOBENZYLAMIRNE AT PH4.6
Descriptor:Urokinase-type plasminogen activator, 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION, ...
Authors:Jiang, L.G., Zhang, X., Huang, M.D.
Deposit date:2017-09-06
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
5YC7
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THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH 4-BROMOBENZYLAMIRNE AT PH7.4
Descriptor:Urokinase-type plasminogen activator, 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION
Authors:Jiang, L.G., Zhang, X., Huang, M.D.
Deposit date:2017-09-06
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
5Z1C
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THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH 4-IODOBENZYLAMINE AT PH7.4
Descriptor:Urokinase-type plasminogen activator, 1-(4-iodophenyl)methanamine
Authors:Jiang, L.G., Zhang, X., Luo, Z.P., Huang, M.D.
Deposit date:2017-12-25
Release date:2018-12-26
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 49, 2018
3G7N
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CRYSTAL STRUCTURE OF A TRIACYLGLYCEROL LIPASE FROM PENICILLIUM EXPANSUM AT 1.3
Descriptor:Lipase, SULFATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Bian, C.B., Yuan, C., Chen, L.Q., Edward, J.M., Lin, L., Jiang, L.G., Huang, Z.X., Huang, M.D.
Deposit date:2009-02-10
Release date:2010-02-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD
Proteins, 78, 2010
6A8G
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THE CRYSTAL STRUCTURE OF MUPAIN-1-IG IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:muPAin-1-IG, Urokinase-type plasminogen activator chain B, PHOSPHATE ION
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-08
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5
To Be Published
6A8N
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THE CRYSTAL STRUCTURE OF MUPAIN-1-IG-2 IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:Urokinase-type plasminogen activator B, CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-09
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5
To Be Published
5ZC5
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UPA-NU-09F
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(4-fluoranyl-1-benzofuran-2-yl)pyrazine-2-carboxamide
Authors:Jiang, L.G., Buckley, B.J., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-15
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5Z65
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CRYSTAL STRUCTURE OF PORCINE AMINOPEPTIDASE N ECTODOMAIN IN FUNCTIONAL FORM
Descriptor:Aminopeptidase, N-ACETYL-D-GLUCOSAMINE, ZINC ION
Authors:Sun, Y.G., Li, R., Jiang, L.G., Qiao, S.L., Zhang, G.P.
Deposit date:2018-01-22
Release date:2019-01-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Characterization of the interaction between recombinant porcine aminopeptidase N and spike glycoprotein of porcine epidemic diarrhea virus.
Int. J. Biol. Macromol., 117, 2018
5ZA7
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UPA-HMA
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide, SULFATE ION
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-06
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZA8
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UPA-BB2-27F
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(1-methylpyrazol-4-yl)pyrazine-2-carboxamide
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-06
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZA9
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UPA-BB2-50F
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-6-(1-benzofuran-2-yl)-Ncarbamimidoyl-pyrazine-2-carboxamide
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAE
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UPA-6F-HMA
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide, SULFATE ION
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAF
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UPA-BB2-28F
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(furan-3-yl)pyrazine-2-carboxamide
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAG
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UPA-BB2-94F
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-pyrimidin-5-yl-pyrazine-2-carboxamide
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAH
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UPA-BB2-30F
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2-methoxypyrimidin-5-yl)pyrazine-2-carboxamide
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
5ZAJ
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UPA-31F
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-07
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018