7VM5
Crystal structure of uPA in complex with 4-guanidinobenzoic acid
Summary for 7VM5
| Entry DOI | 10.2210/pdb7vm5/pdb |
| Descriptor | Urokinase-type plasminogen activator, TRIETHYLENE GLYCOL, 4-carbamimidamidobenzoic acid, ... (4 entities in total) |
| Functional Keywords | upa, serine protease, 4-guanidinobenzoic acid, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 28044.95 |
| Authors | Jiang, L.G.,Huang, M.D. (deposition date: 2021-10-07, release date: 2022-10-12, Last modification date: 2023-11-29) |
| Primary citation | Zhou, Y.,Wu, J.,Xue, G.,Li, J.,Jiang, L.,Huang, M. Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys.J., 121:3940-3949, 2022 Cited by PubMed: 36039386DOI: 10.1016/j.bpj.2022.08.034 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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