3OY5
The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4
Summary for 3OY5
Entry DOI | 10.2210/pdb3oy5/pdb |
Related | 2NWN 3OX7 3OY6 |
Descriptor | Urokinase-type plasminogen activator, MH027, SULFATE ION, ... (4 entities in total) |
Functional Keywords | urokinase-type plasminogen activator, peptidyl inhibitor, pharmacophore, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 2 |
Total formula weight | 30792.94 |
Authors | Jiang, L.G.,Andreasen, P.A.,Huang, M.D. (deposition date: 2010-09-22, release date: 2011-08-10, Last modification date: 2023-11-01) |
Primary citation | Jiang, L.G.,Svane, A.S.P.,Sorensen, H.P.,Jensen, J.K.,Hosseini, M.,Chen, Z.,Weydert, C.,Nielsen, J.T.,Christensen, A.,Yuan, C.,Jensen, K.J.,Nielsen, N.C.,Malmendal, A.,Huang, M.D.,Andreasen, P.A. The binding mechanism of a peptidic cyclic serine protease inhibitor J.Mol.Biol., 412:235-250, 2011 Cited by PubMed: 21802428DOI: 10.1016/j.jmb.2011.07.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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