3OY5

The crystal structure of uPA complex with peptide inhibitor MH027 at pH7.4

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0004252	molecular_function	serine-type endopeptidase activity
U	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 U 1

Chain	Residue
U	LYS62
U	ASN87
U	PRO170
U	HIS170
U	HOH281

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site_id	AC2
Number of Residues	28
Details	BINDING SITE FOR CHAIN P OF MH027

Chain	Residue
P	HOH104
U	ARG35
U	PRO49
U	HIS57
U	CYS58
U	ASP60
U	TYR60
U	TYR64
U	HIS99
U	SER146
U	THR147
U	ASP189
U	SER190
U	CYS191
U	GLN192
U	GLY193
U	SER195
U	SER214
U	TRP215
U	GLY216
U	GLY219
U	GLY226
U	HOH258
U	HOH313
P	HOH17
P	HOH38
P	HOH43
P	HOH67

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
U	ILE53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
U	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
U	HIS57
U	ASP102
U	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681

Chain	Residue	Details
U	SER146

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
U	GLN145

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